4I8O


Conserved Protein Domain Family
RNLA_N_2
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cd14795: RNLA_N_2 
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N-terminal repeat domain of toxin RnlA; second out of two repeats
The Escherichia coli toxin RnlA functions as an mRNA endoribonuclease and is part of a two-component toxin-antitoxin system that promotes resistance to phage infections, together with the antitoxin RnlB. RNAse activity is located in the C-terminal domain. This N-terminal domain appears to participate in homodimerization and is the second out of two repeats.
Links
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Statistics
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PSSM-Id: 269818
Aligned: 10 rows
Threshold Bit Score: 112.466
Created: 12-Nov-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:4I80: The N-terminal repeat domain of Escherichia coli RnlA is involved in homodimerization, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #  ## ###           #                             
4I8O_A       100 QVNXVLQGFVETSVLPVLELSADE---SHIEFREHSRNA--HTVVWKIISTsYQDELTVSLHITTGKLQIQGRPLSCYRV 174 Escherichia col...
WP_007647779  99 NVNMVIQGIVKDQLDAVLELTSEQ---ANLEIKVHSKTP--STIVWKIVSTeFQDELTISFHVNTFNLQIQGRPLSCYRV 173 Shewanella sp. ...
YP_001501138 100 SVNMVVDGFIEESISPVLLCTADE---TYIELQEHHREA--SKIVWKLISIeFQDELTVTLHTTTRLLQIQGRPLSCYRA 174 Shewanella peal...
WP_023327883  98 NVNYSLKGITTESFDPILECVLEA---GDIELNLLRDED--NCKQVTLKSIaHQDHLTLTHHRRTRVLQIQGKPLSCYRR 172 Klebsiella pneu...
WP_001286808  95 SVNLSIDGIRAEDFDAVIACINNS---GEFEIEINRDEP--VCKQITLKSIvHQDQLKLTSHRSTRNMQIQGKPLSCYRR 169 Vibrio cholerae
WP_023128609   1 MNLGIKGVDLDDAEALIKELTESAn--ADIEVASRTSAD--RKHIWKLKSKkNLDELTVTQHENTHKLQIQGRPLSCYQQ 76  Pseudomonas aer...
YP_130024     94 KANLVLKGMSSDEIEFVLALMGDElveGEKAFSITTANPtpICQKYTITCDkFKDNIVLLYHTTTYKLQIQGRALFCYRT 173 Photobacterium ...
WP_017103266  98 KVNLVLKGFIESMLSPVLEVINEE---AHIEINEYSRDK--LRVVWKILSKeYQDEITVTLHKTTRTLQVQGRPLSCYRA 172 Vibrio tasmanie...
AGZ36374      98 TINLAIKGIDLSDAQALIKELTESa-eADIGIDSYTGAD--RRHIWKLKSKkNSDELTVTQHETTNNLQIQGRPLSCYQQ 174 Pseudomonas sp....
YP_066883     92 SVNCTFKGLLEEEFGIFEEYVIEEl--PDISSKIQKDDK--TKKTISYSGK-YSDTVTVTFYKTTGTTLLQGRPLPAFFE 166 Desulfotalea ps...

Feature 1                   
4I8O_A       175 FTFNLAALLDL 185 Escherichia coli K-12
WP_007647779 174 FIFNLTSLLDL 184 Shewanella sp. HN-41
YP_001501138 175 FIFNLTELLDL 185 Shewanella pealeana ATCC 700345
WP_023327883 173 VIFMLTDLLDL 183 Klebsiella pneumoniae
WP_001286808 170 VIFMLTDLLDL 180 Vibrio cholerae
WP_023128609  77 LSYLLTELLEI 87  Pseudomonas aeruginosa
YP_130024    174 LCYHLSALLDQ 184 Photobacterium profundum SS9
WP_017103266 173 FIFNISELLDL 183 Vibrio tasmaniensis
AGZ36374     175 LSYLLTEILEI 185 Pseudomonas sp. VLB120
YP_066883    167 IKALFAGIVES 177 Desulfotalea psychrophila LSv54

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