1ZY9,1KTB,2F2H


Conserved Protein Domain Family
GH_D
?
cd14790: GH_D 
Click on image for an interactive view with Cn3D
Glycoside hydrolases, clan D
This group of glycosyl hydrolase families is comprised of glycosyl hydrolase family 31 (GH31), family 36 (GH36), and family 27 (GH27). These structurally and mechanistically related protein families are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. They have a wide range of functions including alpha-glucosidase, alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase, alpha-N-acetylgalactosaminidase, stachyose synthase, raffinose synthase, and alpha-1,4-glucan lyase.
Links
?
Statistics
?
PSSM-Id: 269891
Aligned: 4 rows
Threshold Bit Score: 229.816
Created: 25-Sep-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitecatalytic site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2F2H_A; Escherichia coli YicI xylosidase binds XTG (4-nitrophenyl-(6-S-alpha-D-xylopyranosyl)-beta-D-glucopyranoside); defined at 4A contacts.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                         ##                          
1ZY9_A    195 TPTGWCswyhyf----------ldltweETLKNLKLAKn-----fPFEVFQIDDAyek----digDWLVTrgDFPsv-eE 254 Thermotoga maritima
1KTB_A      9 PPMGWLawerfrcnvncredprqcisemLFMEMADRIAedgwrelGYKYINIDDCwaakqrdaegRLVPDpeRFPrgikA 88  chicken
2F2H_A    269 FGLWLTtsftt------------nydeaTVNSFIDGMAer---nlPLHVFHFDCFwmka--fqwcDFEWDplTFPdp-eG 330 Escherichia coli
AAH70098  314 RDPIWStwalygr--------avdqdkvLRFAQQIRLHh-----fNSSHLEIDDMytp----aygDFDFDevKFPna-sD 375 human

Feature 1                                                                                     
1ZY9_A    255 XAKVIaenGFIPGIWTAPFSvsetsdvfnehpdwvvkengep--kxayrnwnkkiyaldlskdevLNWLFDLFssl-rkx 331 Thermotoga maritima
1KTB_A     89 LADYVharGLKLGIYGDLGRltcgg-----------------------------------ypgttLDRVEQDAqtf-aew 132 chicken
2F2H_A    331 MIRRLkakGLKICVWINPYIgqkspvfkelqekgyllkrpdg-slwqwdkwqpglaiydftnpdaCKWYADKLkgl-vam 408 Escherichia coli
AAH70098  376 MFRRLrdaGFRVTLWVHPFVnynssrfgegverelfvreptgrlpalvrwwngigavldfthpkaRDWFQGHLrrlrsry 455 human

Feature 1          # ##                                                #                      
1ZY9_A    332 GYRYFKIDFLfagavpgerk----knitpiqafRKGIETIRKavg-----edSFILGCGspllpa----------vgcvd 392 Thermotoga maritima
1KTB_A    133 GVDMLKLDGCyssg----------------keqAQGYPQMARalna--tgrpIVYSCSWpayqgglppkvnytllgeicn 194 chicken
2F2H_A    409 GVDCFKTDFGeriptdvqwfdgsdpqkmhnhyaYIYNELVWNvlkdtvgeeeAVLFARSasvga------------qkfp 476 Escherichia coli
AAH70098  456 SVASFKFDAGevsylprdf-----styrplpdpSVWSRRYTEmalpf-fslaEVRVGYQsqn---------------isc 514 human

Feature 1       #   #                                                                         
1ZY9_A    393 GXRIgPDTapfwgehiedngapaARWALRNAITRyfxh----drfwLNDPDClilreek----------------tdltq 452 Thermotoga maritima
1KTB_A    195 LWRNyDDIqds---------wdsVLSIVDWFFTNqdvlqpfagpghWNDPDMliignf------------------glsy 247 chicken
2F2H_A    477 VHWG-GDCy-------------aNYESMAESLRGglsig--lsgfgFWSHDIggfent-------------------apa 521 Escherichia coli
AAH70098  515 FFRL-VDRdsv---------wgyDLGLRSLIPAVltvsm---lgypFILPDMvggnavpqrtaggdvperelyirwleva 581 human

Feature 1                        # #                       
1ZY9_A    453 keKELYSYTCGvl--dNXIIESddlslv-----rdhgkkVLKETL 490 Thermotoga maritima
1KTB_A    248 eqSRSQMALWTim--aAPLLMStdlrtis---psakkilQNRLMI 287 chicken
2F2H_A    522 hvYKRWCAFGLl---sSHSRLHgsksyrvpwayddescdVVRFFT 563 Escherichia coli
AAH70098  582 afMPAMQFSIPpwrydAEVVAIa---------------qKFAALR 611 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap