Conserved Protein Domain Family
FHb-globin_3
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cd14783: FHb-globin_3 
Globin domain of flavohemoglobins (flavoHbs); uncharacterized subgroup
FlavoHbs function primarily as nitric oxide dioxygenases (NODs, EC 1.14.12.17), converting NO and O2 to inert NO3- (nitrate). They have an N-terminal globin domain and a C-terminal ferredoxin reductase-like NAD- and FAD-binding domain, and use the reducing power of cellular NAD(P)H to drive regeneration of the ferrous heme. They protect from nitrosative stress (the broad range of cellular toxicities caused by NO), and modulate NO signaling pathways.
Links
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Statistics
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PSSM-Id: 271316
Aligned: 8 rows
Threshold Bit Score: 252.381
Created: 18-Sep-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:heme binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                   #            ###        #  ##  ##                  ##
AEP09954       2 LDQKTIDIVKSTAPVLDQHGETLTRHFYQRMFTHNPeVAPFFNpaHQKSGSQQRALAAAICAYAANIDNLevLGNAVELI 81  Micavibrio aeru...
ADI37840       2 LSQQTIDLVKSTVPILQEQGETLTKYFYKRMFSQNPeVAPYFNsaNQTEGAQQRALAEAICTYAANIDNLnaLKETLEQI 81  Waddlia chondro...
EET21564       9 LSQKNIDTIKATIPILEENGVALTKHFYDRMFRHNPeVKKFFNtsRQKNSSQPEALAVAILAYAKNIENLevLGNAVELI 88  Francisella phi...
CBW27276      17 LESKTIEIIKSTAPILEEHGVLLTKHFYKKLFEKNPeVMPYFNraHQEMGTQQEALAGAICAYAKNIDNLsaLSGAVSLI 96  Bacteriovorax m...
NP_870404     11 LSEKTIRIVKEITPLVAANAETITRRFYERMFEANPeVKAFFNqaHQHSGGQQKALAGAICAYFTHIDNPavLMPAVELI 90  Pirellula sp. 1
AFI83261       1 MKPETFDIIRQTVPVLEQHGELLADCFYKNMFHNNPeVKAFFNpaHQHSGAQQRALAATICAYARHIENFdqLQQLIGLI 80  Methylophaga sp...
WP_009964669   2 LSPQTIAIVKATAPVLEQNGELLTRHFYERMFRHNPeVAPFFNraNQTSGSQQKALAAAICAYAANIDNLevLGGAVELI 81  Verrucomicrobiu...
Q7UIY1         2 LSEKTIRIVKEITPLVAANAETITRRFYERMFEANPeVKAFFNqaHQHSGGQQKALAGAICAYFTHIDNPavLMPAVELI 81  Rhodopirellula ...

Feature 1          ##  # #   ##  #                           #  #   #        
AEP09954      82 AQKHASLHIKPEHYPIVGENLLASIREVLGdaaTDDIINAWANAYGFLANILINREAQIY 141 Micavibrio aeruginosavorus ARL-13
ADI37840      82 AHKHASLMIKPQHYPIVGANLLASIREVLGedaTDDVIHAWSHAYDFLANILTGREKQIY 141 Waddlia chondrophila WSU 86-1044
EET21564      89 AQKHASLQIKAEHYPIVGFNLIESIKEVLDlndNDDIVIAWTEAYNLLAEILINREKSIY 148 Francisella philomiragia subsp. phi...
CBW27276      97 ANKHSSLKIKPEHYPIVGVNLLESIKEVLGdgaTDDIISAWKKAYFFLADILIEAEKNLY 156 Bacteriovorax marinus SJ
NP_870404     91 AQKHVSLGIKPEHYPIVGSNLLAAIGDVMGdaaTPEIVEAVSEAYGFLADIFIGREGAIY 150 Pirellula sp. 1
AFI83261      81 SQKHVSFGIKPEHYPIVENHFLLALREVMGesaTEEVIEAWTEAYGVLAGIFIDKEDDLY 140 Methylophaga sp. JAM1
WP_009964669  82 AQKHASLQIKAEHYPIVGTNLLASIREVLGsaaTDDIVNAWAEAYQFLADILIGRESQIY 141 Verrucomicrobium spinosum
Q7UIY1        82 AQKHVSLGIKPEHYPIVGSNLLAAIGDVMGdaaTPEIVEAVSEAYGFLADIFIGREGAIY 141 Rhodopirellula baltica SH 1

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