1UX8,2BKM


Conserved Protein Domain Family
TrHb2_Bs-trHb-like_O
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cd14772: TrHb2_Bs-trHb-like_O 
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Truncated hemoglobins, group 2 (O); Bacillus subtilis TrHb like
The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb2's belonging to this group include monomeric Bacillus subtilis trHb (Bs-trHb), which exhibits an extremely high oxygen affinity, and a dimeric TrHb2 from the thermophilic aerobic spore forming bacterium Geobacillus stearothermophilus(Gs-trHb).
Links
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Statistics
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PSSM-Id: 381281
Aligned: 9 rows
Threshold Bit Score: 202.64
Created: 14-Dec-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heme binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:2BKM: Geobacillus stearothermophilus TrHb2 binds acetate ion/oxygen molecule/heme; contacts at 4A
  • Structure:1UX8: Bacillus subtilis TrHb2 binds heme; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #           ###       #  ##  #          #        #  ##  # #    
1UX8_A      9 YEAI-GEELLSQLVDTFYERVASHPlLKPIFPs--DLTETARKQKQFLTQYLGGPpLYTEEHGHPMLRARHLPFPITNER 85  Bacillus subtilis ...
2BKM_A      7 YEAIgGEETVAKLVEAFYRRVAAHPdLRPIFPd--DLTETAHKQKQFLTQYLGGPpLYTAEHGHPMLRARHLRFEITPKR 84  Geobacillus stearo...
NP_294726  13 YDRI-GPDTLALLVHRFYAHVARNPdLAPIFPa--DLSETARKQLAFLTGFTGGPpLYHELYGHPRLRARHLPFPITPGR 89  Deinococcus radiod...
EES73266    8 YDNLgGEETIRRLVEAFYPRVQRDPlLGPLFPe--DITPVMEKQFMFLSQFFGGPsLYSDAFGHPMMRARHLPFPVTTER 85  Paenibacillus sp. D14
ADH99063   10 FDRI-GEEELSALVDRFYTYVKADPlIRDLFPd--DMGETIRKQKQFLTQFCGGPqLYTNEHGHPMLRMKHIPFVITKPK 86  Bacillus selenitir...
EGL83586   10 YYRFgGEKTLRQLVEIFYDKVARHPdLAPIFPd--DFTLTKEKQFKFLSQFFGGPdLYTRAYGHPMLRARHLRFPITPTR 87  Caldalkalibacillus...
EGK11288   17 YERIgGDETITRIVESFYPRVQKDPlLAPIFPkgdEIRPVMEKQRRFLTQFFGGPpLYSQLYGHPRMRARHLPFPITPRR 96  Desmospora sp. 8437
EKN68362    7 YEMLgGEEIIQKLVNSFYPKVYANPiLSPLFEg--DMEEIKRKQKMFLTQFTGGPtLYSDEFGPPAMRARHMPFEITPTR 84  Bacillus azotoform...
ADG07299   12 YELIgGAETVQRLVNAFYKRVGQHPdLKPIFPe--DLTPVARRQYKFLTQFFGGPpLYSQEYGPPMLRARHMPHPITPKR 89  Kyrpidia tusciae D...

Feature 1     #  #                         #   #  #  
1UX8_A     86 ADAWLSCMKDAMDHVg-LEGEIREFLFGRLELTARHMVN 123 Bacillus subtilis subsp. subtilis str. 168
2BKM_A     85 AEAWLACMRAAMDEIg-LSGPAREQFYHRLVLTAHHMVN 122 Geobacillus stearothermophilus
NP_294726  90 ARAWLACMNAALRETpgLAEADAHELYAALARVAVHMVN 128 Deinococcus radiodurans R1
EES73266   86 AEAWLACMKAALEEIg-VEEPLRGIVLERLSGPAFHFVN 123 Paenibacillus sp. D14
ADH99063   87 SDAWLSCMSQALEESl-MDEYTKQELLARLTYTANHMIN 124 Bacillus selenitireducens MLS10
EGL83586   88 ARAWLACMQETLDELg-LEDRIKQEMMMRFTYTAQHMIN 125 Caldalkalibacillus thermarum TA2.A1
EGK11288   97 AEAWLRCMAEALDETg-IQGQVREEMWSRLYTTAAHMVN 134 Desmospora sp. 8437
EKN68362   85 ATAWLACMREAMDDIg-LEGPIREQFYDRLQQVAGIMIN 122 Bacillus azotoformans LMG 9581
ADG07299   90 AKAWLSCMAEALEEAg-IEEPMRGFLFQRLTMTAHHMIN 127 Kyrpidia tusciae DSM 2912

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