3VMN,3VMO


Conserved Protein Domain Family
GH66
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cd14745: GH66 
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Glycoside Hydrolase Family 66
Glycoside Hydrolase Family 66 contains proteins characterized as cycloisomaltooligosaccharide glucanotransferase (CITase) and dextranases from a variety of bacteria. CITase cyclizes part of a (1-6)-alpha-D-glucan (dextrans) chain by formation of a (1-6)-alpha-D-glucosidic bond. Dextranases catalyze the endohydrolysis of (1-6)-alpha-D-glucosidic linkages in dextran. Some members contain Carbohydrate Binding Module 35 (CBM35) domains, either C-terminal or inserted in the domain or both.
Links
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Statistics
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PSSM-Id: 270613
Aligned: 50 rows
Threshold Bit Score: 290.297
Created: 2-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Structure:3VMO; Streptococcus mutans dextranase with bound Isomaltotriose, contact 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                         ## #                 #  #       
3VMN_A        117 TFPRYAAIGGSqkdnns----vltknlPDYYRELEQMKn-mNINSYFFYDVYKSATNPfpn-vpkFDQSWNWWSHSQve- 189  Streptococcus...
3VMO_A        117 TFPRYAAIGGSqkdnns----vltknlPDYYRELEQMKn-mNINSYFFYDVYKSATNPfpn-vpkFDQSWNWWSHSQve- 189  Streptococcus...
Q59979         76 VFPRYGIVAGSptdqns----ilvknlEAYRKELELMKs-mNINSYFFYDAYNEATDPfpegvdsFVQKWNTWSHTQvd- 149  Streptococcus...
WP_020619185   99 EAPRYGFLSDFap-------------gDVDDSDLAFLRr-hHINIVQFYDWMYRHDQLvp----dAEDEFTEPLGRRis- 159  Paenibacillus...
WP_003746451  101 IFPRYGVVAGSndnsaernnsmtndqlEGYQNNIDQLAq-mHINNYFFYDVYDTTSNPfpn-vnsFKQEWATWAVNNgkp 178  Neisseria mucosa
WP_003868300   32 LAPRYGFLSDFfd------------rdKNDDKDLVQLNk-yHINVVQFYDWMYRHHELl-----pPTNSFADPLGRNls- 92   Thermoanaerob...
CDB88289       84 QVTRYAFLSDFts-------------aDTETQDVDWLRr-lHFNAVQFYDWMYRHDMLl-----pPQERYLDPMGREtd- 143  Firmicutes ba...
YP_003117644  175 RFPRYGYMTNNsfgnq-------glstSQAASIMSSMSn-yHIDGLQFYDWQYNHDQPlcgtvsaPCSSWTDDGNQKtvy 246  Catenulispora...
WP_009748126  106 QRLRYGFVASYa--------------pDKDVEAVARLArklHLNGIQFYDWAYRHADLv-----gGGETYLDPLDQPis- 165  Actinomyces s...
WP_004252519  214 VYPRYGVVAGSkdnhns----itkdqvEGYKNSIDQLAn-mHVNNYFFYDVYNTPGNPfpanverFTQDWATFLIPKdet 288  Streptococcus...

Feature 1                                          # #                                            
3VMN_A        190 -------------tdAVKALVNRVHQTGAVAMLYNMILAQNAnet---------avlPDTEYIYnyetgg------ygqn 241  Streptococcus...
3VMO_A        190 -------------tdAVKALVNRVHQTGAVAMLYNMILAQNAnet---------avlPDTEYIYnyetgg------ygqn 241  Streptococcus...
Q59979        150 -------------tkAVKELVDQVHKSGAVAMLYNMISADSNp--------------KNPALPLaalaynfydsfgkkge 202  Streptococcus...
WP_020619185  160 -------------lsVVSRKIRGLEAGGMAAMAYAAVYASLSdy-----------aeAHPEQLLynn------------g 203  Paenibacillus...
WP_003746451  179 npp-------qidtlLIKNLVNKIHEKGGSAMLYNMLNAASNd--------------ELDNPAIkdilnnv----klyna 233  Neisseria mucosa
WP_003868300   93 -------------idVVKQKIDYAHKFGMMAIAYGAVYGCEKef-----------yeEHKVWALykn------------d 136  Thermoanaerob...
CDB88289      144 -------------laAIRAKIAACKAAGIRPIAYGAVYAAAKel-----------faEHPEWAMytm------------d 187  Firmicutes ba...
YP_003117644  247 -------------asAVKDLVTAAHNSNIVAMPYNAIFSADNgsccgapdyhtqglgVSPSWGVyq-------------- 299  Catenulispora...
WP_009748126  166 -------------leTVRRLIRALAQAGSRSFGYAAVYGVGNe--------------EWDQWKDaalmq---------cd 209  Actinomyces s...
WP_004252519  289 dpekrktylpvidteAVKELVSHVHSTGAKAMLYNMIYAVSLdekipd----qvksaIVRNLQD---------------- 348  Streptococcus...

Feature 1                                                            ##                           
3VMN_A        242 gqVMTYSidd----kpLQYYYNPLS-KSWQNYISNAMAQAMKnggFDGWQGDTIGDNrvlshnqkd-------------- 302  Streptococcus...
3VMO_A        242 gqVMTYSidd----kpLQYYYNPLS-KSWQNYISNAMAQAMKnggFDGWQGDTIGDNrvlshnqkd-------------- 302  Streptococcus...
Q59979        203 pmTYTIGdn------pTQVYYDPAN-PDWQKYIAGVMKSAMDrmgFDGWQGDTIGDNrvtdyehrn-------------- 261  Streptococcus...
WP_020619185  204 gqPYKLGd--------YYHIMDISPdSAWTPHILAEFAKVIDy-gFHGLHLDQYGFPkqairrvg--------------- 259  Paenibacillus...
WP_003746451  234 qeHSNFGkagaetktsVQQFVDPAD-KSWQNYIVNTMIKALKtggFDGWQADTMGDNlvykiqng--------------- 297  Neisseria mucosa
WP_003868300  137 gtVFDLIn--------LIYIMDISKkCGWHDHIISEFLKAIKf-gFDGIHMDQYGFPkealsvtd--------------- 192  Thermoanaerob...
CDB88289      188 gqAMTFAg--------WLYYMNIAPsCGWSEHILAEFRKAVAf-gFSGIHMDTYGFPkqvwda----------------- 241  Firmicutes ba...
YP_003117644  300 dtNHSKPla-----ffQWDYMDPSN-PGWQQYLMGQQNAAIQafdFDGFHGDTFGDPdtvdynyngqpagvasdscttdt 373  Catenulispora...
WP_009748126  210 gtPYELGg--------FLQIVDPAA-RAWLAHFIADLQKCVEqvgFQGFHLDQYGYPkyatra----------------- 263  Actinomyces s...
WP_004252519  349 --HFNFGktgdvtatdIQQFLDPGD-PNWQNFIINVMLKAMKeggFDGWQGDTMGTNlvekvne---------------- 409  Streptococcus...

Feature 1                                                      #                       #          
3VMN_A        303 ---------srdiahsfmLSDVYAEFLNKMKEKLpq----yYLTLNDVNg--eNISKLAns-kqDVIYNELWPfgtsalg 366  Streptococcus...
3VMO_A        303 ---------srdiahsfmLSDVYAEFLNKMKEKLpq----yYLTLNDVNg--eNISKLAns-kqDVIYNELWPfgtsalg 366  Streptococcus...
Q59979        262 ---------stdeadshmMSDSYASFINAMKDLIge---kyYITINDVNg---GNDDKLakarqDVVYNELWTnggsvip 326  Streptococcus...
WP_020619185  260 -----------greevvrLKESYPSFIAQTREALps----aGLIFNNVSsypvHTTADSp---qDAMYIEVWDpv----- 316  Paenibacillus...
WP_003746451  298 -----------qktenfrMSDGYDDLSAAAAEKLhdy--gqTYMINDISt---GRADVLsttgmDVPYSEIWPrdfkdta 361  Neisseria mucosa
WP_003868300  193 -----------qvkkirkLRDEFTVLINDTREYIekngykpALIFNAVNn--wPIDTVAsa-kqDVVYIEVWPpn----- 253  Thermoanaerob...
CDB88289      242 ------------errpveLTDALPKLIDRAAEAVrkedsaaGVIFNAVNn--wPMEAVAgt-kqDAVYIEVWPpn----- 301  Firmicutes ba...
YP_003117644  374 dgahsttpvhnvagsatwLSGTFPSFLSYAKSALgs---gkYLMFNPVTyd-hAHCEANts-avDLLYSELWPndrd--- 445  Catenulispora...
WP_009748126  264 ------------dgelidLSQSFTKMINAARDGLpd----tVLVFNNVNd--fPTWATAgt-pqDAVYIEPWVpi----- 319  Actinomyces s...
WP_004252519  410 ------------pgkafsLSDNYPKLAAAATEALkke--gyDFMINDISt--gDADRLGkt-nvSAPYAEVWGdsia--- 469  Streptococcus...

Feature 1                                                                                         
3VMN_A        367 ---nrpqesYGDLKARVDQVRQat--------gKSLIVGAYMEepkfddnripln---gaardvlasatyQTDAVLLTTA 432  Streptococcus...
3VMO_A        367 ---nrpqesYGDLKARVDQVRQat--------gKSLIVGAYMEepkfddnripln---gaardvlasatyQTDAVLLTTA 432  Streptococcus...
Q59979        327 ---grmqvaYGDLKARIDMVRNkt--------gKSLIVGAYMEepgidytvpggkatngagkdalagkplQADATLLVDA 395  Streptococcus...
WP_020619185  317 -------atLEQLKENIDRAREls--------gKQVILAAYLPcfqkds---------------gvpqqeAEIGATVAMA 366  Paenibacillus...
WP_003746451  362 gnthyenhnYAELKRLVGRLYDyn--------hVSPIIAAYTQkgthpe---------------dhsselNPDNELLVDA 418  Neisseria mucosa
WP_003868300  254 -------dtYQDLYNLITNAKKya-------pdKQVILAAYMEpfskrs---------------nipieyAENATIMVMA 304  Thermoanaerob...
CDB88289      302 -------drYYDLYTLIREARLcs--------gKQVVLAAYLHpfqqa------------------dtdgAERAFRLSWA 348  Firmicutes ba...
YP_003117644  446 -----qywdYGSLKTAIDQGFSesasasptgrgKSLTVAAYTDfangg------------------ggtfNTPDVLLLDS 502  Catenulispora...
WP_009748126  320 -------ttLGALAGVAARARSva-------qgKPVVLAAYQSvyska------------------sveeSEQANKLTMA 367  Actinomyces s...
WP_004252519  470 -----hdstYQALTRLTERMRDly-------ngKSPIIAAYTHrekn-------------------atklSKDNELLTDA 518  Streptococcus...

Feature 1                                       #### #                       
3VMN_A        433 AIAAaGGYHMSLaalanp--ndgggvGVLETAYYPTQSlkvSKELNRKNYHYQQFITAY 489  Streptococcus mutans
3VMO_A        433 AIAAaGGYHMSLaalanp--ndgggvGVLETAYYPTQSlkvSKELNRKNYHYQQFITAY 489  Streptococcus mutans
Q59979        396 TVAAaGGYHMSIaalan----anaalNVLQSAYYPTQYlsvAKDTIRKLYNYQQFITAY 450  Streptococcus salivarius
WP_020619185  367 SIFAsGGYHLLLge-----------qGNVLADSYYPNYgqvSDAFAATLTRYYDFIVMY 414  Paenibacillus daejeonensis
WP_003746451  419 VIAAsGGYHMTVaalnnhpdknahgfGILQDPYYPAQTlktNEALAKSEFNYQQFITAY 477  Neisseria mucosa
WP_003868300  305 TIFAsGGFHLLLge----------lnGILTEAYYPNYTtidSERFIRELRDYYDFIVRY 353  Thermoanaerobacter ethanolicus
CDB88289      349 AICAaGGTQLVLge-----------nKAALQDSYYANYaalRPSFLPVVQRYCDFLVRY 396  Firmicutes bacterium CAG:170
YP_003117644  503 TLFAsGGSHEELgd----------ngLMLDYQEYRAGAtpmSASLSQSVQNYYDFMTAY 551  Catenulispora acidiphila DSM 44928
WP_009748126  368 TLFShGATQLLAge-----------gGNVLVDPYYVNNhqaADSTLEMLKRWYDFLVEH 415  Actinomyces sp. oral taxon 181
WP_004252519  519 IIAAsGGYHMTTaalnts--qdekgfGVIQAEWYLNQNlpvNADFANAEFNYQEFIVAY 575  Streptococcus mitis

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