4HS2,4HXI,3HVE,4AP2,2EQX


Conserved Protein Domain Family
BACK
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cd14733: BACK 
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BACK (BTB and C-terminal Kelch) domain
The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.
Links
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Statistics
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PSSM-Id: 350515
Aligned: 937 rows
Threshold Bit Score: 29.1661
Created: 11-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4HS2_A         34 SVENAAEILILADLHs-----aDQLKTQAVDFINYHas-------------------------------dvLETSGWKSM 77   human
ESO05061      157 NDKTCFYIHHLAKQHn-----lSSLLNMIDSYVFVNin-------------------------------rlVQSGLYLDI 200  Helobdella ro...
OWF40354       18 TNENVVYIFNLAEMFc-----lNSMQKYCVSVMRKSlh-------------------------------evTKSEDFIKL 61   Yesso scallop
XP_022647379  139 NHTNVLALYQLANRYs-----lLDLHEECMLYVLENck-------------------------------elFDRRDFLEE 182  honeybee mite
PFX27354      369 SGSNVMQVMYLANKYm-----vPSLAEKCTEHLRDN-----------------------------------LTAANVLSI 408  Stylophora pi...
XP_012937068  446 LEKDLPEWKQLAKQLe-----sDTLQSKIMVFMSTLapmplkqavgillrnydgiekplaievvkdkfqdiLDASDVLYQ 520  California se...
XP_018670466  370 SIENAPGIMELAQRHs-----lTELQQLATLECVTHfs-------------------------------nlRSSSDYLCM 413  vase tunicate
OXU28347      136 ETKNVFAMLHLAKLVpg----cTSLLERTEKFIRRNlr-------------------------------evSLTDSYRNV 180  Trichomalopsi...
EXX74220      129 KAEWIEQHFAFTHRTsfqsnslLGLQKFCTDFMDKSpe-------------------------------kvFKSLDFTSL 177  Rhizophagus i...
CDW52022      456 DEKNIVSRVKLAKVVg-----pTVLSQVLSNYIIKNrh--------------------------------vLSSDDWKKM 498  human whipworm

4HS2_A         78 vvsh---------------------phlVAEAYRS 91   human
ESO05061      201 tl------------------------pmLEIYLGR 211  Helobdella robusta
OWF40354       62 dv------------------------gkMTQIVRG 72   Yesso scallop
XP_022647379  183 ipf-----------------------efVKKIVER 194  honeybee mite
PFX27354      409 lphaqnfedkdledrcwkrealnvkeveLFKAVDR 443  Stylophora pistillata
XP_012937068  521 fsl-----------------------ddMLEVVSS 532  California sea hare
XP_018670466  414 ss------------------------qlFEVILSR 424  vase tunicate
OXU28347      181 di------------------------elLKSILSR 191  Trichomalopsis sarcophagae
EXX74220      178 se------------------------tsLISLIKK 188  Rhizophagus irregularis DAOM 197198w
CDW52022      499 erdd---------------------psaSAFILKE 512  human whipworm
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