3AT7,4BGO


Conserved Protein Domain Family
Imelysin-like_EfeO

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cd14656: Imelysin-like_EfeO 
Click on image for an interactive view with Cn3D
EfeO is a component of the EfeUOB operon
This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.
Statistics
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PSSM-Id: 271139
Aligned: 133 rows
Threshold Bit Score: 95.3948
Created: 22-Nov-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved motif
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Conserved motif, 3 residue positions
Conserved feature residue pattern:G H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:Conserved motif is GXHXXE
  • Citation:PMID 7674922
  • Comment:The HxxE motif is present in zinc-dependent M75 proteases, but no zinc is present in the Algp7 structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3AT7_A        31 LVQPISDYKIYVSENLQTLVRDTREFTNAVKagd------------------------vaKAKKLFASTRMSYERIEPIA 86  Sphingomonas sp...
Q4JYE9       173 VTDVSIAHARAQKPQVREWVSKDDALLRAVRsgd------------------------raAAQEAWKTAYLAYRRLDDSN 228 Corynebacterium...
Q1QSA1       144 FLGALAEYKVYLTLQSRRLIDAADTLHRAIEdgd------------------------laAARDAYAQARLIDQRLAMAT 199 Chromohalobacte...
YP_001634264  33 VTSNLSGIKDYLLGQTRALVTATADLQTASNryydlaqatnfdyaslwqnqqreviaalnAAREAWITASPIYEKMEGIV 112 Chloroflexus au...
WP_005278025 116 VESDAFTVTGSTVSNAPKMVPITDHEVAAVSikqaenqkervp------elqkrahaladATSSSRSAAKAAYLDYLEYY 189 Corynebacterium...
WP_005324121 154 TDREVAAVAIQQAAEQKKRVPELQKKAHALAd----------------------------ATSKNRPTARAAYLDYLETY 205 Corynebacterium...
ADD29187      43 LAEAAGRYEAIVRNAGFKYASLAQQHGPAIRna-------------------------lrDARIAWIKASPIYESVEGIV 97  Meiothermus ruber
YP_001543248  32 AAGELGAIKTYLLGKTGDLINSSTALETASQryydlakaanfdyatlwsskqaevgtalnDAKAAWLKSSPTYEQMEGIV 111 Herpetosiphon a...
YP_006271499  16 GAADLSGVKTYLDGRLGRMVQGTQALGTAADryyelaraakfdyr-rlaaqpqavraalnAARAGWEKASPLYEDVEGIV 94  Deinococcus gob...
WP_019952136 146 IIGVLAEYRVSTILQLRELHQRIDTLAAAISdgd------------------------neAMRHAWLAARRSERQLALVL 201 Kushneria aurantia
Feature 1                                                    # #  #                              
3AT7_A        87 El---FSDLDASIDSRADdhekae--------------kdpaffGFHRIEYGLFaqnsa--------------------- 128 Sphingomonas sp...
Q4JYE9       229 He--wPGPVDDIADFGTSskangn--------------qakdlsGYHRLEWGLWhgdpl--------------------- 271 Corynebacterium...
Q1QSA1       200 Gl---FSDLDQRLNARAEyfaqrd--------------edpnfiGFQRLAQGLFeastt--------------------- 241 Chromohalobacte...
YP_001634264 113 AgtpaLAQFDVDLDAGAAgsedpenavsfdlvlpdgrtlpkpgnLFGVTESTLWgtdpafaapvsadwngd-gtiefget 191 Chloroflexus au...
WP_005278025 190 Rs---FDDSSAEWPGPDLe-------------------------GYEDIERILWsnrppsd------------------- 222 Corynebacterium...
WP_005324121 206 Rs---FDDSSEMWPGPDLe-------------------------GYAEVEKLLWskrpvkd------------------- 238 Corynebacterium...
ADD29187      98 AgvelLSDFDLNLDAGASgaeggdavvtfdlklangkvlprpgnLFGVLEGSLWgserafssgvafdvdgd-grigfgdq 176 Meiothermus ruber
YP_001543248 112 AgvssLADFDVTLDAGASaeeggdsvvnydltladgrtiakpgnLFGVTESTLWgtydafrvtdveadingngtvefges 191 Herpetosiphon a...
YP_006271499  95 AgvesLSRFDVILDAGTSaaeggenvvpfdlklpsgrvlarpgnLFGVNEGALWgtvkayssgvpfdlngn-griefgeq 173 Deinococcus gob...
WP_019952136 202 Dll-aEQDGDSSADNPLSa-------------------------DLQQLEKGLFesnas--------------------- 234 Kushneria aurantia
Feature 1                                                                                        
3AT7_A       129 ----kglaPVADKLMADVLELQKRIrglt--------fppeKVVGGAAVLMEEVAATKISG-----EEDRYSHTDLWDFQ 191 Sphingomonas sp...
Q4JYE9       272 ----galvAPAEKLNQNVHEVADGTeqfa--------ifapNYGLRTHEVTEEVERFDLKS-----HNDFGAHITGSAVR 334 Corynebacterium...
Q1QSA1       242 ----aglaPVSAQLRDDVRTLAERWr---------------HQAIPPAQLASGSARVLAAWhdhaiDQAPLDARELLDLR 302 Chromohalobacte...
YP_001634264 192 lpdanvlkASADLLAQMANDLDSTAqnwtptes-daftalvVMVPTMSEYFASWRDSRFVLgdastQRDFNVISRLADIQ 270 Chloroflexus au...
WP_005278025 223 --aalpatALADATDKTAHALDTAHfai----------papDYGLRAHEVMEEFERFDLRG-----ERDFGAHALPAALR 285 Corynebacterium...
WP_005324121 239 --aakparALADAVDKTARALETSHfai----------papDYGLRTHEVMEEFERFDMRG-----ERDFGAHALPTALR 301 Corynebacterium...
ADD29187     177 lpdalilrAAAEKLDAMTGELLATArtwkptaqdvfralaaNVPTAASVFIERWKTSRFVLgdkatRRDFNVISSLDDLI 256 Meiothermus ruber
YP_001543248 192 lpeanvllAAAQKLKATATELDTAAkaweptdt-dafsalvVMVPTMNEYFDSWKNSRFVAgdsstQRDFVAISRLADIG 270 Herpetosiphon a...
YP_006271499 174 lpdanvlkAAAAELGAQGRALQAAAqawsptredvfgaligNVPTVGPVFFEDWKTSPFVLgakstRKDFVAISRMSDLV 253 Deinococcus gob...
WP_019952136 235 ----vsttAAINRLRENLEHLTPPLkals--------iepsQLADTSAGLLRHWHDRQRSAg----EPAALAVNDLAGLT 298 Kushneria aurantia
Feature 1                                                                                        
3AT7_A       192 ANFEGAKKIVDLFRPlvvkdnraFADKVDANFDTVFKTLAKYrt-------adGGFELYgk--lsERDRKVLAGRVNTLA 262 Sphingomonas sp...
Q4JYE9       335 AALYSTRSTLDPLRD--------LVEDRGADLRELDKQLDRTdkvakkmaakyDGKKPFta--weQADQRELGAAIGKLN 404 Corynebacterium...
Q1QSA1       303 GLLQGADKIASLLGPl-------LESRDPQTLSRLTSELAAL-----------KTALPEsg---tAADRDALLTETRALS 361 Chromohalobacte...
YP_001634264 271 DILSGLEVVYAQVRPrveavdpaQAEQIATGLRDLRAFVADIytqe----rngRRFSPEeadtlgAEAQNRATAITGQIS 346 Chloroflexus au...
WP_005278025 286 GVITSTRVTLDPVRSlved-rglDTAPIYDQLADLDSLAEEFdd-------kyGGASSVafadwpQEDRLRLQAGVAKAN 357 Corynebacterium...
WP_005324121 302 GNVTSTRLTLDAVRSlveg-rglDTAPIYDQLDELDKIAGEFd----------EKYDTAfdk-wsQKDRMRLQSAVARAN 369 Corynebacterium...
ADD29187     257 NNITSWQQLYGGVAQlvqaknpsLDRQIRDGLASLRTWVQRLaaq-----ektRRFTPEqaemilKEGDNRATAVTGKIV 331 Meiothermus ruber
YP_001543248 271 DILGSLQVVYDSLSPkvaaldadQDRQIKTNLQALRDFVADVykke----qagQHFTAEesdllgAEAQNRADAITGQVS 346 Herpetosiphon a...
YP_006271499 254 GNVGSWQAMYRGLSAdvkarnpaLDGQIGAGLRDLSALAGRLvar-----ektRRYTPEqaealqKEAQNRATVVAGRIT 328 Deinococcus gob...
WP_019952136 299 HGVDSVVRLLTPLLEpra---pdVLQQVRAALSALQASLADDt----------TTGTSAiq--rlNERSLALADALTGIN 363 Kushneria aurantia
Feature 1               
3AT7_A       263 EDLSKMR 269 Sphingomonas sp. A1
Q4JYE9       405 ELLAPLA 411 Corynebacterium jeikeium K411
Q1QSA1       362 RTLSEIN 368 Chromohalobacter salexigens DSM 3043
YP_001634264 347 QMAGALG 353 Chloroflexus aurantiacus J-10-fl
WP_005278025 358 ELLAPVA 364 Corynebacterium accolens
WP_005324121 370 ELLAPVA 376 Corynebacterium pseudogenitalium
ADD29187     332 QAAALLG 338 Meiothermus ruber
YP_001543248 347 QIAARLN 353 Herpetosiphon aurantiacus ATCC 23779
YP_006271499 329 QAAALLG 335 Deinococcus gobiensis I-0
WP_019952136 364 PALDMHA 370 Kushneria aurantia

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