1QP9,1HWT,2HAP


Conserved Protein Domain Family
ZIP_Hap1
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cd14655: ZIP_Hap1 
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Leucine zipper Dimerization domain of transcription factor Hap1 and similar fungal proteins
Hap1p mediates oxygen sensing and heme signaling in yeast. In response to heme, it promotes transcription of genes required for respiration and controlling oxidative damage. It is a member of the Gal4/Gal4p family of transcriptional activators which contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Hap1p binds to DNA containing a direct repeat of two CGG triplets. It is a large protein that contains repression modules (RPMs) and heme-responsive motifs (HRMs) in addition to the DNA-binding and dimerization domains.
Links
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Statistics
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PSSM-Id: 271239
Aligned: 8 rows
Threshold Bit Score: 32.3415
Created: 11-Jun-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceDNA bindingcoiled coil
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1QP9: Saccharomyces cerevisiae Hap1p dimer; contacts at 4A.
  • Structure:2HAP: Saccharomyces cerevisiae Hap1p dimer; contacts at 4A.
  • Citation:PMID 9886287
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  ## ##  ## ##  ## ##  
1QP9_A     45 TWAEEAEKELLKDNELKKLRERVKSLEKTLSK 76   baker's yeast
1HWT_C     45 TWAEEAEKELLKDNELKKLRERVKSLEKTLSK 76   baker's yeast
2HAP_C     45 TWAEEAEKELLKDNELKKLRERVKSLEKTLSK 76   baker's yeast
EEH48344  227 GHPIPRGDRQRLRKEKKDLIKELRKLRWARGR 258  Paracoccidioides brasiliensis Pb18
GAC71966   62 PHIRSVTRSRASGSRTSSALHADHQPQAHQPD 93   Pseudozyma antarctica T-34
CCH46162   74 PWIQIISSENQIYEEIKSLKKENDLLIKNITL 105  Wickerhamomyces ciferrii
EEQ37146   47 SWVDPRMKVAASGEVVVLPVEESKEYQELRKS 78   Clavispora lusitaniae ATCC 42720
CCH45876   71 HWVNNVMNAEAKSETILLPQVSPDSQQSNHKE 102  Wickerhamomyces ciferrii

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