3COQ,1HBW


Conserved Protein Domain Family
ZIP_Gal4
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cd14654: ZIP_Gal4 
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Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins
Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.
Links
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Statistics
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PSSM-Id: 271238
Aligned: 61 rows
Threshold Bit Score: 46.0572
Created: 11-Jun-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceDNA bindingcoiled coil
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:3COQ: Saccharomyces cerevisiae Gal4p dimer; contacts at 4A.
  • Structure:1HBW: Saccharomyces cerevisiae Gal4p dimerization domain dimer; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ## ##  ## ##  ### # ###        #  #       ##  #   
3COQ_A     43 TRAHLTEVESRLERLEQLFLLIFPRe---DLDMILKMDSLQDIKALLTGL 89  baker's yeast
BAE63525   45 TRQHLTYVEDRLQAFETALGRLFPGg---DLDATADGFDWTENKITVGDL 91  Aspergillus oryzae RIB40
EGU87633   61 TRRQLTLLEERLEKAETVLRRHYTDg---QIAEMLEGPKEGLVTQNQQVP 107 Fusarium oxysporum Fo5176
GAA85782   51 TRQHLTYVEERLQAFETALSRLFPGg---DLDATVRSLLHDQEGPPKPGS 97  Aspergillus kawachii IFO 4308
EHK20177   54 TRRHLTEVEERLEQAEALIRQLRAAl---PPQTLSSEGSSNTIDSPNQLS 100 Trichoderma virens Gv29-8
EHK42249   20 TRKHLTEVEERLEQAEALIRQLRHAe---SSEKSHEDDFESPPSTGEFGW 66  Trichoderma atroviride IMI 206040
EHK46776   29 TRRHLTQVEEELARANALLRELQPQq---ECKEMNESSTSLSKDNTVDRE 75  Trichoderma atroviride IMI 206040
EHY60755   56 TRKHLTEVEERLEKAEALLRTVFTEa---QLAEMLAHGASAGTNHAFRGT 102 Exophiala dermatitidis NIH/UT8656
ELA27506   71 TRKHLTEVEERLERAEALITHMRTLl---PTNTRSGSSLATPGRPEPPAP 117 Colletotrichum gloeosporioides Nara gc5
ETS02719   20 TRRHLTEVEERLEQAEALIRQLRAAlpqhTILSEGSNNTPASPSEISHDG 69  Trichoderma reesei RUT C-30

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