1AJY,1ZME


Conserved Protein Domain Family
ZIP_Put3
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cd14651: ZIP_Put3 
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Leucine zipper Dimerization domain of transcription factor Put3
Put3p activates the transcription of PUT1 and PUT2 genes in the presence of proline, allowing yeast cells to use proline as a nitrogen source. These genes encode for proteins that convert proline to glutamate, which is a metabolically more useful form of nitrogen. Put3p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.
Links
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Statistics
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PSSM-Id: 271236
Aligned: 4 rows
Threshold Bit Score: 49.788
Created: 11-Jun-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceDNA bindingcoiled coil
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1AJY: Saccharomyces cerevisiae Put3p dimer; contacts at 4A.
  • Citation:PMID 9303003
  • Structure:1ZME: Saccharomyces cerevisiae Put3p dimer; contacts at 4A.
  • Citation:PMID 9303004
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #### ##  ## ##  ## ##  ##  ## #
1AJY_A        41 VVSTKYLQQLQKDLNDKTEENNRLKALLLEX 71  baker's yeast
1ZME_C        40 VVSTKYLQQLQKDLNDKTEENNRLKALLLER 70  baker's yeast
EEQ38950      67 EISRLSIQSLEIKLRETTEELNRLRMEKKGK 97  Clavispora lusitaniae ATCC 42720
XP_002617632  67 EISRLSIQSLEIKLRETTEELNRLRMEKKGK 97  Clavispora lusitaniae ATCC 42720

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