Conserved Protein Domain Family
PTPc-N20
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cd14596: PTPc-N20 
catalytic domain of tyrosine-protein phosphatase non-receptor type 20
Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization.
Links
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Statistics
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PSSM-Id: 350444
Aligned: 6 rows
Threshold Bit Score: 402.589
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitecatalytic site
Feature 1: active site [active site], 10 residue positions
Conserved feature residue pattern:x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q4JDL3        208 YINASYIRIvncgEEYFYIATQGPLlsTIDDFWQMVLENnsNVIAMITREiegGIIKCYHYWPislkkplelkhFRVFLE 287  human
XP_010561825 1930 YINASYITMkvgeEEHFYIITQGPLpsTMADFWQMVWESesDLIAMMTKEvelGQVQCHRYWPepphdtidlanFHLRLD 2009 bald eagle
XP_009305698 1945 YINASYIRMkvgsEELFFISAQGPLpgTQDSFWQMVWENrsDVIAMMTREverGRVKCHKYWPekldvpketsrYQLFLD 2024 zebrafish
XP_014341837 2026 YINASSIMMrvgeEEHFYISTQGPLprTIGDFWQMVWESrsDVIAMMTREverGRVKCHRYWPvtlnnpmnvngYQLFLV 2105 coelacanth
XP_007902819 1969 YINASYIQMpvgaTKRLYIACQGPLpgTTSDFWQMIWESkaTLIAMMTREherGKVKCHRYWPdtasqpmmvgkYQLRLE 2048 elephant shark
XP_012823194 1783 YINASYVTVpvgeKKLRYICTQGPLpdTVNYFWQMVWENhsSVIIMMTQEresGKVKSEQYWPeqiqetwkgenLSLRLE 1862 tropical claw...

Feature 1                                            ##                            #######        
Q4JDL3        288 NYQILqYFIIRMFQVVekstgtsHSVKQLQFTKWPDHGTPasADSFIKYIRYARKSHLTgPMVVHCSAGIGRTGVFLCVD 367  human
XP_010561825 2010 NYQIVeYVIIRIIEMInkqteekRTISHLQFTTWPDHNTPklAEQLVKFICYMRKVHSTgPIVAHCSTGIGRSGVLLCIE 2089 bald eagle
XP_009305698 2025 NYQMLgYFHIKVIKMVekksgdvHFVKHLKFTTWPDHGTPhsSDQLVRFIRYMRAVHAKgPITVHCSAGIGRAGVLICTD 2104 zebrafish
XP_014341837 2106 NYQVLeSFIISIIKVTenetgdtRLVKHLQFTTWPDHGTPksSKQLVQFICYFRKIYQSgPAIFHCSAGIGRAGVLICID 2185 coelacanth
XP_007902819 2049 NDQALdSFNVKSLKLVdnetgeaRDIKHLHFVTWSDHGTPqsSEQLVRFILYMRHVHRLgPVVVHCSAGIGRAGVLICTD 2128 elephant shark
XP_012823194 1863 KCNALqDFTIRIMTLFqketgenRLITHLQFTTWPDHSTPqsPQSLLHFLCYLRRFHNEwPLVVHCSAGIGRTGVLICVH 1942 tropical claw...

Feature 1                                      #                 
Q4JDL3        368 VVFCAIvkNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414  human
XP_010561825 2090 VLLSYIekDLCFSIKQIVRDLRNQRFGMIQTKDEYLFCYEVVLEVLQ 2136 bald eagle
XP_009305698 2105 VILSLIqkDLSINVSDIVKEMRLQRHGMIQTKEQYLFCYKVWLEVLQ 2151 zebrafish
XP_014341837 2186 VLLSLIqkDLSFNIVDIVREMRQQRYGMIQTKEQYEFCYKVMLEVLQ 2232 coelacanth
XP_007902819 2129 VLLSLIdkNLSFEIMAIVREMRKQRHGMIQTKDQYLFCYKVVLEILQ 2175 elephant shark
XP_012823194 1943 VILTYLeqGIQFQIKDIVKTMRQQRYGMIQTKDQYIFCYKALLTALR 1989 tropical clawed frog

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