Conserved Protein Domain Family
PTP-MTMR10

?
cd14593: PTP-MTMR10 
protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
Myotubularin related phosphoinositide phosphatase 10 (MTMR10) is enzymatically inactive and contains an N-terminal PH-GRAM domain. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. MTMR10 is a pseudophosphatase that lacks the catalytic cysteine in its catalytic pocket.
Statistics
?
PSSM-Id: 350441
Aligned: 6 rows
Threshold Bit Score: 378.851
Created: 19-Oct-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q9NXD2       279 RRMPLWCWshsngSALVRMALIKdvLQQRKIDQRICNAITKSHPQRSDVYKSDLDKTLPNIQEVQAAFvKLKQLCVNEPF 358 human
Q6NU08       266 RRMPLWCWnhsngSALVRMASIKdlLQQRKIDQRVCSGITRSHPLRSEVYKCDLDDNVPSIQDIQAAFsKLRQLCVNEPF 345 African clawed ...
A0JMF6       264 QRIPLWCWnhpsgSALVRMSNISdpQQQRKVEQRISSAITKSHPLRSDVFKSDLDKNLPNIQDIQAALlKLRQICVIESF 343 zebrafish
EMC81238     236 RRMPLWSWnhpngSALVRMANIKdvLQQRRIDQRICNAITRSHPLRSDVYKSDLDKCLPNIQEIQAAHiKLKQLCVNEPF 315 domestic pigeon
XP_007908180 282 GRIPMWCWqhssgSALVRMANVRpgVQLRKHDTRILKAITQSHPQRSEVFKSDLDKTLPSLQEIQAAFhRLKQLCISDLF 361 elephant shark
XP_014348373 267 GRIPMWCWchpngSALVKMASIKdlLQQRKIDQRICNAITRSHPQRSDVYKLDLDKTLLPIQEIQAASvRLKQLCINDPF 346 coelacanth
Q9NXD2       359 EETEEKWlsslentrWLEYVRAFLKHSAELVYMleskhlSVVLQEEEGRDLSCCVASLVQVMLDPyfrtitGFQSLIQKE 438 human
Q6NU08       346 DETEEKWlsslentrWLEFVRMFLKQAAELVYMldfsrrSVVLQEEEGRDLSCVVASLVQLMLDPyfrtiiGFQSLIQKE 425 African clawed ...
A0JMF6       344 EESEEKWlsslessrWMEYVRTFLRHAVEVVYMlesrhvSVILLEKEDRDLSCVISSLVQLMCDPhcrslhGFQALIQKE 423 zebrafish
EMC81238     316 EETEEKWlsslenthWLEYIRSFLKHSAELVYMmeckhvSVILQEEEGRDLSCLTASLIQIMLDPyfrtivGFQSLIQKE 395 domestic pigeon
XP_007908180 362 EETDEKWssslestrWLEYIRLFLKHSAELTQWldskhiSVVIQEEEGRDLSCVVASVVQVMLDPhfrsiqGFQSLIQKE 441 elephant shark
XP_014348373 347 EETDEKWfsllestrWLEYVRAFLKHSAELVFMleckhvSVILQEEEGRDLSCVVSSLVQVMLDPyfrtttGFQSLIQKE 426 coelacanth
Q9NXD2       439 WVMAGYQFLDRCNHlkr-----sekESPLFLLFLDATWQ 472 human
Q6NU08       426 WVMSAYPFLDRCNHlkr-----sdkESPLFVLFLDCVWQ 459 African clawed frog
A0JMF6       424 WVMAGHRFLDRCNHlkksdkeelwnQYPAAFEFTEVYLT 462 zebrafish
EMC81238     396 WVMAGYQFLDRCNHlkr-----sdkESPLFLMFLDCVWQ 429 domestic pigeon
XP_007908180 442 WVIAGYRFLDRCNHlqks----dkqECPLFLLFLDCVWQ 476 elephant shark
XP_014348373 427 WVMAGYRFLDRCNHlkks----dkeESPLFLLFLDCVWQ 461 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap