2BZL


Conserved Protein Domain Family
PTPc-N21_14
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cd14540: PTPc-N21_14 
catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and type 14 (PTPN14) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Both PTPN21 and PTPN14 contain an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.
Links
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Statistics
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PSSM-Id: 350388
Aligned: 7 rows
Threshold Bit Score: 365.241
Created: 28-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 10 residue positions
Conserved feature residue pattern:x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2BZL_A        100 YINASHIKVvvggaewHYIATQGPlp-hTCHDFWQMVWEQgvNVIAMVTAEeeg-grTKSHRYWPklgskhssatygkFK 177  human
XP_002117889  529 YVNASYVTMevgdkvlRYIAAQAPlq-nTVEDFWQMIWEQqvALIVMVTAEqen-stNKCFTYWPdmaigs-teyfepYS 605  Trichoplax ad...
XP_001750093 4083 YINANHVTFaeegrtlWYIAAQGPlp-gTVGDFWRMVWEQgsQIVVMVTGEveg-gkVKCERYWPtetgeydalvfgdLK 4160 Monosiga brev...
XP_002404238  833 YINASHVSAsvgdsqrFYIAAQGPmq-tTAKSFWQMVWENhvGVVVMLTDTeddqghEKCYQYWPqangeeaalsfgeYR 911  black-legged ...
XP_002431259  876 YINASHITAtvgnsqrFYVAAQGPls-sTVDTFWQAVWEVdaYLVVRLTSKe----eEDCFTYLPassdhc--lqlgeYQ 948  human body louse
NP_609013    1036 YVNASSISAtvgtkqrFYIVAQSPqeplTMRIFWQCVWEAdvYLVVQLTEDmsy-ipRNSHQRLEfg----------qFQ 1104 fruit fly
Q16825        950 YINASHIKVsvsgiewDYIATQGPlq-nTCQDFWQMVWEQgiAIIAMVTAEeeg-grEKSFRYWPrlgsrhntvtygrFK 1027 human

Feature 1                                                  ##                                     
2BZL_A        178 VTTKFRTDSvcYATTGLKVKhlls--gqeRTVWHLQYTDWPDHGCPedVQGFLSYLEEIQSVrrhtnsmlegtknrhpPI 255  human
XP_002117889  606 VSSKTFHAAsaYVIRTFAVEntai--gqsRIIYHIQFVGWPDHGVPdhVDKFLEFYNKMNAIrnriyqa---tdqfepPT 680  Trichoplax ad...
XP_001750093 4161 ISLVKSVSSgnYTIRGLRVRnmse--dlmRTVWHLQYTAWPDHSVPktPSSLLDFIDEIREIrvrlmgv--avnnppwPT 4236 Monosiga brev...
XP_002404238  912 VVRKSAVSSavAVTTCLVLSrtqgvscthRNVWHLRYTDWPDHGTPgdVQGFLGFMEEVDSVrrlalndq-rlrtrnaPT 990  black-legged ...
XP_002431259  949 IWKEFSQETghCLTSRLRVQhtta--rrsRSIWHLQYTDWGDQGCPssPSHFLGFLEELNSVrlhtiedvpaghnrnpPV 1026 human body louse
NP_609013    1105 VYQEFSQTTdrCTTIKLRLYhvps--rryRSVWYLQYADWAEQNCPrdVNHFLDFLEELNSVrlastqevppghntnpPV 1182 fruit fly
Q16825       1028 ITTRFRTDSgcYATTGLKMKhllt--gqeRTVWHLQYTDWPEHGCPedLKGFLSYLEEIQSVrrhtnsts-dpqspnpPL 1104 human

Feature 1            #######                                     #                
2BZL_A        256 VVHCSAGVGRTGVLILSELMIYCLehNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 319  human
XP_002117889  681 LVHCSAGVGRTGVVMLADLMIAYIknQWELNIPAVLAKMRKQRMYLVQTYQQYEFVYLSLIQYI 744  Trichoplax adhaerens
XP_001750093 4237 VVHCSAGVGRTGVLMLVESELIRLeqGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA 4300 Monosiga brevicollis MX1
XP_002404238  991 VVHCTAGVGRSGVVILCDILLFCLdhNVPVDLPRVLTLVRMQRMLSVQTLAQYKFVHQVLIRYL 1054 black-legged tick
XP_002431259 1027 LVHCSDGVGRTGVTILCDLVLYTLdhNQEVDVPRVVALLRHQRMLMVQNVAQYHFTFNLLLTYL 1090 human body louse
NP_609013    1183 LLHCLEGGGRSGVTLTADLLLYTLdhNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL 1246 fruit fly
Q16825       1105 LVHCSAGVGRTGVVILSEIMIACLehNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL 1168 human

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