1WCH


Conserved Protein Domain Family
PTPc-N20_13
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cd14538: PTPc-N20_13 
catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13
Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) and type 13 (PTPN13, also known as PTPL1) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization. Human PTPN13 is an important regulator of tumor aggressiveness.
Links
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Statistics
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PSSM-Id: 350386
Aligned: 9 rows
Threshold Bit Score: 372.092
Created: 28-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 10 residue positions
Conserved feature residue pattern:x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1WCH_A        100 YINASFIKIpvgk--eefVYIACQGPlptTVGDFWQMIWEQksTVIAMMTQEvegekIKCQRYWPnilgkt-tmvsnrLR 176  human
XP_001630367   83 YINANHIRVlvdd--dtyHYIATQGPlpnTTKDFWQMIWEQgvEVVAMVTLDkeggkVKCHRYWPdntnqp-lklggrFE 159  starlet sea a...
XP_002610408  407 YINASHVRIpvgs--dtfHYIASQGPlpvTAGSFWQMVWEQraEVIAMVTLDmeggkVKCHRYWPdssetp-ltfwnkYE 483  Florida lancelet
XP_006812581 2258 YINASFIRWsvgn--spyHYIACQGPlphTTGDFWQMIWEQkvEVIAMVTMDmengkVKCHRYWPdsvdtp-milqgrYE 2334 Saccoglossus ...
XP_009053452  124 YINASYINIdied--tqlRYIACQGPlpnTVDDFWLMCWQEevSVVAMLTLDvesrrVKCHRYWPdspietldicdgeYE 201  owl limpet
ELT89390       61 YMNASHVRLnlaggraylSYLACQGPlpnTTHDFWRMVWEQkaQVIAMVTQEveaskVKCHRYWPdtsmv---vcegcLE 137  Capitella teleta
XP_011679925  196 YINASHIKAqvgk--dtyEYIACQGPlpnTTQDFWLMVWEQraDVIAMVTMDvesgkVKCHRYWPesansp-lmvynrIE 272  purple sea ur...
Q4JDL3        208 YINASYIRIvncg--eeyFYIATQGPllsTIDDFWQMVLENnsNVIAMITREieggiIKCYHYWPislkkp--lelkhFR 283  human
XP_012823194 1783 YINASYVTVpvge--kklRYICTQGPlpdTVNYFWQMVWENhsSVIIMMTQEresgkVKSEQYWPeqiqet--wkgenLS 1858 tropical claw...

Feature 1                                                ##                               ####### 
1WCH_A        177 LALVRMQQLkgFVVRAMTLEdiqtrevRHISHLNFTAWPDHDTPsqPDDLLTFISYMRHIHRs---gPIITHCSAGIGRS 253  human
XP_001630367  160 VSLLKQTNYdsFVQRDIAVKhlqsgksIEIAHLNFVKWPDHGVPrsPVEMVQFVAYMRSLATsq--aPVVVHCSAGIGRT 237  starlet sea a...
XP_002610408  484 VSLVSSQALedFNIRTFSLRdmetsevRSVTHLNFTTWPDHGVLkfADPLLRYTRVIRRFHQs---gPVVVHCSAGIGRT 560  Florida lancelet
XP_006812581 2335 IQMTSLQTLenFDIRRISMSdmktgkeWRLTHLNYTTWPDHGVPvsGLPLVRYMRYMRKIHHs---gPIVVHCSAGIGRT 2411 Saccoglossus ...
XP_009053452  202 VNLKSSQSLndIDIRYINIThcpsgkiKHIIHLNYTTWPDHGTPqsAIPILQFLRLLHLLHTg---gPIVVHCSAGIGRS 278  owl limpet
ELT89390      138 ISKVKQRSLanVGVSWLSMRdtatgetHPVMHLNYTTWPDHGAPlnALPLLRYIRLVHLSENtsdpaPIVVHCSAGIGRT 217  Capitella teleta
XP_011679925  273 VRLENYQNLdnFSIRRILMIdnetsevHHVTQMNFATWPDHSVPstSLPLLRFACHMRRIHDdr--lPIVVHCSAGIGRT 350  purple sea ur...
Q4JDL3        284 VFLENYQILqyFIIRMFQVVekstgtsHSVKQLQFTKWPDHGTPasADSFIKYIRYARKSHLt---gPMVVHCSAGIGRT 360  human
XP_012823194 1859 LRLEKCNALqdFTIRIMTLFqketgenRLITHLQFTTWPDHSTPqsPQSLLHFLCYLRRFHNe---wPLVVHCSAGIGRT 1935 tropical claw...

Feature 1                                             #                
1WCH_A        254 GTLICIDVVLGLIsqDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 306  human
XP_001630367  238 GALIAVDVALGLMerDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL 290  starlet sea anemone
XP_002610408  561 GVLILVDAVIGLVerDQPFDVQKLVEIMREQRQGMVQTKEQYVFCYQCCLEML 613  Florida lancelet
XP_006812581 2412 GTVITIDLILAMIerDLDFSIYEIVQGLRQQRQGMIQTKDQYIFCYKTILEVL 2464 Saccoglossus kowalevskii
XP_009053452  279 GSLMTIDIALLYMehMLPFNIFEIVKYLRQQKYGMIQTKDQYLFCYTACMQVL 331  owl limpet
ELT89390      218 GAFITIDAALKMVqhDSKVDIQKIVQDLRRQRQGMIQTKDQYVFCYQALLQAL 270  Capitella teleta
XP_011679925  351 GTLITIDAILGLIdrDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL 403  purple sea urchin
Q4JDL3        361 GVFLCVDVVFCAIvkNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL 413  human
XP_012823194 1936 GVLICVHVILTYLeqGIQFQIKDIVKTMRQQRYGMIQTKDQYIFCYKALLTAL 1988 tropical clawed frog

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