Conserved Protein Domain Family
PTP-MTMR3-like

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cd14533: PTP-MTMR3-like 
protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatases 3 and 4
This subgroup of enzymatically active phosphatase domains of myotubularins consists of MTMR3, also known as ZFYVE10, and MTMR4, also known as ZFYVE11, and related domains. Beside the phosphatase domain, they contain a C-terminal FYVE domain and an N-terminal PH-GRAM domain. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. They dephosphorylate the D-3 position of phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively.
Statistics
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PSSM-Id: 350381
Aligned: 11 rows
Threshold Bit Score: 354.788
Created: 18-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic siteactive site
Feature 1: catalytic site [active site], 2 residue positions
Conserved feature residue pattern:C RClick to see conserved feature residue pattern help
Evidence:
  • Comment:the catalytic cysteine initiates a nucleophilic attack on the phosphate group of the substrate, forming a transient phosphoenzyme intermediate and releasing the substrate dephosphorylated; the transition state is stabilized by the arginine present in the catalytic pocket

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
Q9NYA4        213 WKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALdpgtratggslstgnndts------------ 280  human
ABW09427      276 SRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFdrgeharhstcanakaqptkgske------- 348  fruit fly
XP_002596720  219 HKRIPSVVWRHRGNGAVIARCSQPEVGWLGWRNSSDEQFLQAIAEACSEdcgnvdtdsdilvnghsgks----------- 287  Florida lancelet
XP_002414638  213 SRRIPTVVWRHHLYGTVIARSAQPEVGWLGWRSPQDENLIQAIADACSVdpgpaiggleslpdehkcly----------- 281  black-legged ...
XP_001631983  210 SGRFPSIVWRHMTNGAVIARCSQPQVGWLGWRSAEDELLLQAIGQACTSdrypsvakllngitvngink----------- 278  starlet sea a...
XP_790636     223 SKRFPSVVWRHKGNGAVIARCSQPAVGWLGWRSEEDERFMSAILDACAMddprknkkschsngyvkse------------ 290  purple urchin
EKC42140      220 LKRFPSVVWRNQRNGAVLVRCSQPEIGFFNWRNTEDENLMKAFSEACEQnpgksqknpnised----------------- 282  Pacific oyster
EFX75246      304 ARRLPAVVWRHKRNGAVLGRCSQPEVGWLGWRSQEDETLLLSILNSCFYdsannplrsrhptpnkdmnstneewngegsl 383  common water ...
CCD78481      193 HNRFLTVVWRSQVTGAVLLRCAQPCVGLMCSRNEYDEKFLRTVLACCPKkpf---------------------------- 244  Schistosoma m...
XP_002115737  223 LGRIPSVVWRDQASGAVIARSGQPQVAFLGYRCAEDESLIRAIAESSTGdkvnedeltngmvasac-------------- 288  Trichoplax ad...
Q13615        215 WKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASdsrssgsklstrntsrdfpng---------- 284  human
Feature 1                                                                                         
Q9NYA4        281 -------eacdadfdssltacsgvesTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYP-------------NCEVVF 340  human
ABW09427      349 --tngqsglsgksspslddssheeltLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYP-------------CAEIEF 413  fruit fly
XP_002596720  288 -------vflkvlkeicvsngsqeekPADPHKVLIMDARSYAAAVANRAKGGGCECPEYYP-------------NCEVQF 347  Florida lancelet
XP_002414638  282 ------imlpslvsllcgagmhfeprSAPQRKMLILDARSYAAAVANRAKGGGCECPEYYP-------------NCEVQF 342  black-legged ...
XP_001631983  279 ------khdmgdvlngpadmsedgpiARNPKQVLIVDARSYTAAYANRGKGGGFEYTEYYP-------------NCEVMF 339  starlet sea a...
XP_790636     291 --------qyrvtddqdemrrgeyerSNQSKTILIIDARSYAAAFANRAKGGGCEYPEYYT-------------CCDIEF 349  purple urchin
EKC42140      283 ------------tsgsesgsqseedlDGSDKRVMIVDCRSYRASMANRLKGGGVECVEYYP-------------TCDIQF 337  Pacific oyster
EFX75246      384 sisngsssnvecgslkdlsedsscftQGHKKKMLIVDARSYATAVANRARGGGCEFPQYYP-------------QCDIEF 450  common water ...
CCD78481      245 -----------------------sdpNKDTHRLMIVDARSRSSAQFNRIRGGGFEYPEYYD-------------QAEVVF 288  Schistosoma m...
XP_002115737  289 ----------agsledksfynnfspfNMSASLNPLVSSGSYSVEASSSQRRNSFQIIDARSyaaalanramgggLEYPVI 358  Trichoplax ad...
Q13615        285 -----gdlsdvefdsslsnasgaeslAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP-------------NCEVVF 346  human
Feature 1                                                                                 #     # 
Q9NYA4        341 MGMANIHAIRNSFQylravcsqm------pdpsnwlsaLESTKWLQHLSVMLKAAVLVANTVDrEGRPVLVHCSDGWDRT 414  human
ABW09427      414 MNLGNIHAIRKSFHavrqlcass------pddpnwygqLEKTMWMQHLSGLLGATMTVVHTIEkNGRPVLVHCSDGWDRT 487  fruit fly
XP_002596720  348 MGLANIHSIRKSFQavralcsqp------sdqanwlsaLESTKWLQYLSQLMKSVLMVVNAVDlENRPVVVHCTDGWDRT 421  Florida lancelet
XP_002414638  343 MSLANIHTIRKSFHmvrtlcssa------adqsswmstLESSKWLLYLSGLLKASLVVANAVDlERRPVLVHCSDGWDRT 416  black-legged ...
XP_001631983  340 MNLANIHGIRRSFHslralcsgs------ydvpnwwslIEKTNWLHHISMLIKSAVTIVHAVHtDGRPVVVHCSDGWDRT 413  starlet sea a...
XP_790636     350 MGLANIHSVRKSFNtvhalcsnns-----ldqttwlsnLEATKWLQNLSMLLKAAIKVVTAVDqEARPVIVHCSDGWDRT 424  purple urchin
EKC42140      338 MNLDNIHAIRKAFTqlrqhcsta------sdqlnwlssLEGTKWMTYLANLLRTACLVVNVMSkERRSVVVHCSDGWDRT 411  Pacific oyster
EFX75246      451 MNLANIHAVRKSFLllralcqsaignlattdqsnwftqLDSTRWLHHMANLLRASWYTAVNLEeHGRPVLVHCSDGWDRT 530  common water ...
CCD78481      289 MDLPNLHTVRSNFEaltnlfag--------kcpnwfssLEKSSWLNNIGQLLKTASEIAIALEeNARPVMVHCTDGWDRT 360  Schistosoma m...
XP_002115737  359 FNEYGITCLRNYFFswl-------------------anLESTKWFHYLGGLIRTALLVCQSIK-SSRSVLVHCSDGWDRT 418  Trichoplax ad...
Q13615        347 MGMANIHSIRRSFQslrllctqm------pdpgnwlsaLESTKWLHHLSVLLKSALLVVHAVDqDQRPVLVHCSDGWDRT 420  human
Feature 1                                                                          
Q9NYA4        415 PQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQeNVEDQNEQCPVFLQWLDSVHQ 479  human
ABW09427      488 PQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGpNSDEVNERCPVFLQWLDLVHQ 552  fruit fly
XP_002596720  422 PQLVALAELLLDPYYRTIEGFQVLVEREWLDFGHKFADRCGHGcGADDINERCPVFLQWLDCVHQ 486  Florida lancelet
XP_002414638  417 PQIVALAELMLDPYYRTIEGFEVLVEKEWLEFGHKFGDRCGNGvSSEDVSERCPVFLQWLDCVHQ 481  black-legged tick
XP_001631983  414 TQIVALAELLLDPFYRTIEGFKILIDREWLQFGHRFADRCGHG-SDIDENERCPVFLQWLDCVHQ 477  starlet sea anemone
XP_790636     425 PQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRpGQDDANERCPVFLQWLDCIHQ 489  purple urchin
EKC42140      412 SQIVSLAELMMDPYYRTVEGFQVLVEREWLEFGHKFADRCGNGvNSEDPNERSPVFLQWLDCVYQ 476  Pacific oyster
EFX75246      531 PQIVSLAQIMIDPFYRTVKGFQILVQREWIEFGHKFADRCGLLgGCEDTNERCPVFLQFLDCVHQ 595  common water flea
CCD78481      361 PQISSLAQLLADPFYRTIQGFNILVEREWLQFGHKFSDRSGHVsPSLNINEQSPIFLQWLDCVHQ 425  Schistosoma mansoni
XP_002115737  419 SQIVSLAEIMLDPYYRTIEGFIIIIEREWLAFGHKFADRCGHSfPLSESNEQSPVFLQWLDCVHQ 483  Trichoplax adhaerens
Q13615        421 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGeNSDDLNERCPVFLQWLDCVHQ 485  human

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