3CG8,3T9W


Conserved Protein Domain Family
CuRO_1_2DMCO_NIR_like_2
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cd14449: CuRO_1_2DMCO_NIR_like_2 
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The cupredoxin domain 1 of a two-domain laccase related to nitrite reductase
The two-domain laccase (small laccase) in this family differs significantly from all laccases. It resembles the two domain nitrite reductase in both sequence and structure. It consists of two cupredoxin domains and forms trimers, and hence resembles the quaternary structure of nitrite reductases more than that of large laccases. There are three trinuclear copper clusters in the enzyme localized between domains 1 and 2 of each pair of neighbor chains. Laccase is a blue multi-copper enzyme that catalyzes the oxidation of a variety of organic substrates coupled to the reduction of molecular oxygen to water. It displays broad substrate specificity, catalyzing the oxidation of a wide variety of aromatic, notably phenolic, and inorganic substances. Laccase has been implicated in a wide spectrum of biological activities. This subfamily has lost the type 1 (T1) copper binding site in domain 1 that is present in other two-domain laccases.
Links
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Statistics
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PSSM-Id: 259991
Aligned: 3 rows
Threshold Bit Score: 193.252
Created: 23-Jul-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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trinuclear CutrimerDomain 2
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: trinuclear Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:3CG8: Streptomyces coelicolor Laccase binds three Cu ions at trinuclear Cu binding site.
  • Comment:Trinuclear copper site ligands are typically one or two HxH motifs that can be in the same domain/subunit or in different domains/subunits.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                   # #               
3CG8_A     48 VRHLKMYAEKLA--------DGQMGYGFekgkasVPGPLIEVNEGDTLHIEFTNTMDVRASLHVHGLDYEIssd---gta 116 Streptomyces livid...
3T9W_A     29 TRRITMYAEKIS--------DELYGYGLapggatVPGPVLEMWEGDTLEIDLVNTTDRVLSLHPHGVDYDVnsd---gtl 97  Amycolatopsis sp. ...
CAJ73226   38 AVHLEMEAKPLTieprpgvfFDAWGYCLkgdvptVPGPVIKVREGTKVKILFRNKLTVPASIHPHGVKYTTanvgvniag 117 Candidatus Kueneni...

Feature 1                                            # #                        
3CG8_A    117 MNKSDVEPGGTRTYTWRTHkpgrrddgtwrpgSAGYWHYHDHVVGTehgTGGIRNGLYGPVIVRRK 182 Streptomyces lividans TK24
3T9W_A     98 MNGSAVMPGQTRRYTWRSHvgyrradgswaegTAGYWHYHDHAMGTehgTEGVLKGLYGALVVRRQ 163 Amycolatopsis sp. ATCC 39116
CAJ73226  118 NPASIVAPGDSRIFEWDTAg------------TPGTWFYHSYVFERg-gEEGLSRGLWGALIVEPV 170 Candidatus Kuenenia stuttgartiensis

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