4J8C


Conserved Protein Domain Family
Hip_N
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cd14438: Hip_N 
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N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins.
The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this model characterizes the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP.
Links
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Statistics
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PSSM-Id: 271228
Aligned: 51 rows
Threshold Bit Score: 49.469
Created: 2-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4J8C: Rat Hsc70-interacting protein forms a homodimer, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ## ### ##  ##     #   #  ## ### ## #####
4J8C_A          5 PRKVSELRAFVKMCRQDPSVLHtEEMRFLREWVESM-GGKVP 45   Norway rat
XP_003269767  276 LRKVNKPRDFVKMYKQDPSILQtEEMCFLREQVESM-GIYDC 316  White-cheeked Gibbon
ELW70625       13 PHKVTELWAFMKMYKQDPSILHtEEKRFLGEANRGR-RNSKK 53   Chinese tree shrew
NP_001025928    3 SRKLGELRAFVRLCKQNPGLLHtEELGFLREWVESM-GGTIP 43   chicken
NP_001086657    3 PRKVQELREFVRLCQSNPDVLHcPEFKFLTDWIISM-GASVP 43   African clawed frog
EMP34995        3 PKKINELQALVDLYRQDPTLLRaKQLSFLRDSIDSM-GDTVL 43   green seaturtle
XP_004681473    3 SSNVSKLQAFMXMCEQYPSLPHiEEMHFLREQMENT-VGKRA 43   Condylura cristata
ACO12447        4 PNKVHELKELIKVLKQCPHIIHlPELDFFRDYILEM-GGKIP 44   salmon louse
NP_001071978    9 TEKLLILKEFIELFKFNPSVLYeNEMHFVREWILEDlKAQLP 50   Ciona intestinalis
XP_001420414    9 TATLEALRHLVRAAKEDSAILDaPALEFFRRWLEEDlGATIP 50   Ostreococcus lucimarinus CCE9901

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