4I1M,4JVS


Conserved Protein Domain Family
LepB
?
cd14436: LepB 
Click on image for an interactive view with Cn3D
Legionella Rab1-specific GAP LepB
LepB of Legionella, a human pathogen, is a specific RabGAP for Rab1, a member of the largest subfamily of small GTPases. RabGTPases play a role in the control of vesicular trafficking and are switched off by GTPase-activating enzymes (GAPs) that stimulate the intrinsic GTP hydrolysis activity. Legionella LepB is unrelated to the TBC family of human Rab1 RabGAPs.
Links
?
Statistics
?
PSSM-Id: 271226
Aligned: 4 rows
Threshold Bit Score: 325.722
Created: 2-Mar-2014
Updated: 2-Mar-2014
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Structure:4JVS; Legionella drancourtii LepB with bound GDP
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
4I1M_A         23 FSETINQWADILKTtdmekfsFDSNPINLLELVKQFNLYVDELAITCEANNVWAkeridstpnlfalydnsGGEAIHGHA 102  Legionella pn...
4JVS_A         34 FPELIRTWAGLLGQigv--esVRTEEVNFGQLAKCFNDYLNTVAEHCEQQNIWQhkreenhnfftafkpdaSKAALHGHA 111  Legionella dr...
EEZ95750      344 FAEQMNIWLNILSLsde-rsiFDFNSIDRAKLAQKFNFFIDSLLRQAEKIFSFShdlg---------dmglSGKMLQSHS 413  Legionella lo...
WP_010652936  535 FSELLLNWEKRFLPftq-inlIDYSQLDFNDLGQKFNAYVDALAQQAEELNYWGhqpsqtmn-ilnkfftnPPKLELGHA 612  Fluoribacter ...

Feature 1                                  #                                                      
4I1M_A        103 FvpyykeSIVLRRLFTVDpntfnlsRFAAFEGPCQLYCAahadsaWVKIQTLLTLGNGIINTLKIIKQAQAfgi---deA 179  Legionella pn...
4JVS_A        112 YiahykeSVILRHLSIVDpktlgmlRFAPYEAPSTDYCRhfpdspWAKMQRLATAGQNIILQLRLIQNGQMle----ddF 187  Legionella dr...
EEZ95750      414 I------SSFYRNLFTFDa------DLKPFFSSHTKIEVspsevyWQFTETVLTTSFNILVTLRILQDTQNsvmlakssA 481  Legionella lo...
WP_010652936  613 FvgqyreSTVLRRLFSLDlaslgtlRFKPFEEPSEAYRKihpnsyWDNINLLLTAGSDVIAMLRILNKQQSaka--sweE 690  Fluoribacter ...

Feature 1                                                                                         
4I1M_A        180 VTENLKALKEQFIAFQLAeadikeslkapsfaeplpnkESEFFYPIdEKALAKMNGYQLATICLEELNspkpSPLIERIL 259  Legionella pn...
4JVS_A        188 MKEKLPVLQKALDDFMQYktevdallahdsevtpvsthDSSFFYDIdEQTLNAMSGDQLATICFEELNaphpSRLIMRIL 267  Legionella dr...
EEZ95750      482 IHFLFDALKKYLHDFSLL--------------------YQVLLNEL-ENALCIMSDSQLAHVCLHEMDfinsSVLIGMVL 540  Legionella lo...
WP_010652936  691 MAATANLLKDAIERFKKAneaveyfqkn-tpndsvevfESPFFYTIeDEALQKMNGAQLATLCLEELNaktpSVLIKRIV 769  Fluoribacter ...

Feature 1                                               
4I1M_A        260 SnkkFWKRINSAFesgvfkgrtddpaGKIAKIREWHQL 297  Legionella pneumophila subsp. pneumophila str. Philadel...
4JVS_A        268 KsdsLWQEVDDSLngdafmgrqddicEKRNKICQWRQL 305  Legionella drancourtii LLAP12
EEZ95750      541 KnpnLWERMNWALtetqe---ipypeKTANDIMKLQQF 575  Legionella longbeachae NSW150
WP_010652936  770 TdqvLCQRMVQALqdeaae-fnrrkdNVGEKINALCQI 806  Fluoribacter dumoffii

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap