Conserved Protein Domain Family
CUE_DMA_DMRTA1
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cd14417: CUE_DMA_DMRTA1 
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and similar proteins
DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the Drosophila melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice.
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Statistics
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PSSM-Id: 270600
Aligned: 11 rows
Threshold Bit Score: 64.9909
Created: 3-Apr-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5VZB9       325 RPRDPLDILTKIFPnYRRSRLEGILRFCKGDVVQAIEQVL 364 human
AAH70678     272 RQRDPLEILRKVFPnQKQTALESILQYCKGDVVQAIEFVL 311 African clawed frog
EFX84867     361 SKRVPLDTLARLFPqTKRATLKSTLDRCDGDVLRAIEQLV 400 common water flea
Q9VAI8       376 QQRSPIDVLMRVFPnRRRSDVEQLMQRFRGDVLQAMECML 415 fruit fly
EFX89054     190 QHHGSLDMLTRVFPfHPKNAVESALETCGGDVAKAVQQLV 229 common water flea
NP_001033037 229 RDRDPTDIMAKIFPhHKRDTLESMVRTCRGDVVRSIELLM 268 torafugu
AFA46803     283 DHPDPADVMSRIFPqEKRDALAAAVRTCDGDVVRAIELLL 322 Atlantic cod
XP_002400140 111 RRRSPLETLARVFPsRTQASLAAVLDRCQGDVLLAIDEVL 150 black-legged tick
XP_003425134  47 SYRSPVDILMKVFPkKRREDIEMLLRRFRGDVISTMEILV 86  jewel wasp
XP_003742524 285 SKRRPLDTLSKLFPhKESPILAATLARFGGDVCAAIEELM 324 western predatory mite
ACI43916     216 KHRAPIDILTQVFPrHKRNKLDHILGNCKGDVVQAIEQVL 255 ghost shark
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