Conserved Protein Domain Family
UBA_HERC2
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cd14402: UBA_HERC2 
UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
HERC2, also called HECT domain and RCC1-like domain-containing protein 2, is a SUMO-regulated E3 ubiquitin ligase that plays an important role in the SUMO-dependent pathway which orchestrates the DNA double-strand break (DSB) response. Moreover, HERC2 functions as a RNF8 auxiliary factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. In addition to a ubiquitin-association (UBA) domain, HERC2 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain.
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Statistics
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PSSM-Id: 270585
Aligned: 13 rows
Threshold Bit Score: 69.7089
Created: 22-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O95714       2460 PIVVQLMEMGFsRRNIEFALKSLtgasgn----asslpgVEALVGWLLDHSD 2507 Homo sapiens
EDO37196     1923 PAVQQLIEMGFpRQHVEYALKELreee---------dprPELVVAWLLDHPE 1965 starlet sea anemone
EEN67362     1648 PVVQQLIEMGFpRKNVEFALKSLttstg-------etpaAEALVSWLLEHPD 1692 Florida lancelet
XP_003487554 2768 PLVAQLTEMGFpKRSVEFAIKSLstav--------glitAESVVAWLLENPD 2811 Bombus impatiens
NP_001239305 2462 PIVVQLMEMGFpRKNIEFALKSLsgtsgs----asglpgVEALVGWLLDHPD 2509 chicken
EHJ72511     2644 SQVQKVIEMGFsRHAVYGAIQTLggts---------lptVEALVAYLLELPQ 2686 monarch butterfly
XP_003729552 1704 PLVNQMMDMGFpRKHVEFAIKAItgvsd-------aqpgPEAVVNWLVDNPN 1748 purple urchin
XP_003743897 2214 AAQAQLIEMGFpRKSIEAAVKVIktqlgtngivhttspsPESIVAWMLENQE 2265 western predatory mite
EKC31310     2773 PVVTQLMEMGFpKKNVKFALKAIssstlvp---npehpsIEALVGWLIEHPQ 2821 Pacific oyster
JAA64251     1203 PIVRQLVEMGFpRHGVAMALNALagsfh-------vmpsPEAIVAWLLEHEH 1247 Rhipicephalus pulchellus
Q9VR91       2515 QLIGQIMEMGFtRRTVELALKQLslqae-------imptPEQIVQWILEHPD 2559 fruit fly
XP_002937025 2463 PIVVQLMEMGFqRKNIEFALKSLsgasgt----assspgVEALVGWLLDHPD 2510 western clawed frog
XP_686789    1269 PIVLQLMEMGFqRKNIEFALKSLsgttga-----sgvpgVEALVGWLLDHPD 1315 zebrafish
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