Conserved Protein Domain Family
UBA_II_E2_UBCD4
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cd14391: UBA_II_E2_UBCD4 
UBA domain found in Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins
UbcD4, also called ubiquitin carrier protein or ubiquitin-protein ligase, is a class II E2 ubiquitin-conjugating enzyme encoded by Drosophila E2 gene which is only expressed in pole cells in embryos. It is a putative E2 enzyme homologous to the Huntingtin interacting protein-2 (HIP2) of human. UbcD4 specifically interacts with the polyubiquitin-binding subunit of the proteasome. It contains a C-terminal ubiquitin-associated (UBA) domain in addition to an N-terminal catalytic ubiquitin-conjugating enzyme E2 (UBCc) domain.
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Statistics
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PSSM-Id: 270574
Aligned: 15 rows
Threshold Bit Score: 60.392
Created: 22-Mar-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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polypeptide
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Based on structural evidence that Homo sapiens ubiquitin-conjugating enzyme E2-25 kDa (2O25) forms a complex with Sumo-1- conjugating enzyme Ubc9.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                ####                  #  #   #
P52486       163 DSKIQRLRDMGId--EHEARAVLSKEnWNLEKATEGLF 198 fruit fly
EFN85071     163 DDKIRRLTDMGIe--EHSARVALSSYnWDLERATEHCL 198 Harpegnathos saltator
ACO12956     164 DSLLRQLQEMGVd--ETKARVALSSCsWDLHKATEQLF 199 salmon louse
ABI98680     163 ANKVRCLMDLGVg--EQQALVALSSCnWDMDRAIEQLF 198 Pacific white shrimp
EFX77049     163 ENKIRRLKDLGVt--EMNARASLSSCdWDLERATEQIF 198 common water flea
EDW65852     163 DTKVLCLMELGLd--EHEARILLSREnWNLDGATERIF 198 Drosophila virilis
XP_002135033 164 DAKIQDLRELNTsidEHCARLILSKEnWDLEKAADSMF 201 Drosophila pseudoobscura pseudoobscura
XP_002730471 163 SAKVNQLVDMGFt--ETASREALSMHsWDVEKAVEYLM 198 Saccoglossus kowalevskii
XP_790028    163 EQKVKQIVEMGFe--ETCAREALSSScWDVAKAIENLM 198 purple urchin
XP_003382495 166 SAKIDTLLQMGIt--ETKAREALSTHsWNLEAAVDSLF 201 Amphimedon queenslandica

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