2LBC


Conserved Protein Domain Family
UBA2_UBP13
?
cd14387: UBA2_UBP13 
Click on image for an interactive view with Cn3D
UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 13 (UBP13)
UBP13, also called deubiquitinating enzyme 13, Isopeptidase T-3 (isoT3), ubiquitin thioesterase 13, or ubiquitin-specific-processing protease 13 is an ortholog of UBP5 implicated in catalyzing hydrolysis of various ubiquitin (Ub)-chains. It contains a zinc finger (ZnF) domain, a catalytic ubiquitin-specific processing protease (UBP) domain (catalytic C-box and H-box), and two ubiquitin-associated (UBA) domains. Due to the non-activating catalysis for K63-polyubiquitin chains, UBP13 may function differently from USP5 in cellular deubiquitination processes. Moreover, the zinc finger (ZnF) domain of USP13 cannot bind to Ub. Its tandem UBA domains can bind with different types of diUb but preferentially with K63-linked.USP13 can also regulate the protein level of CD3delta in cells via its UBA domains. This model corresponds to the UBA2 domain.
Links
?
Statistics
?
PSSM-Id: 270570
Aligned: 12 rows
Threshold Bit Score: 57.7693
Created: 23-Jul-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Based on structural evidence that Homo sapiens USP5 (3IHP) forms a complex with ubiquitin.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #    ##  ## 
2LBC_A         79 EEIVAIITSMGFqRNQAIQALRATNNNLERALDWI 113  human
F6V6I0        711 EEIVALICSMGFpRNHALQALRATNNNLERALDWM 745  western clawed frog
E1BY77        725 EEMVSIIISMGFqRSLAIQALKATNNNLERALEWI 759  chicken
F1QFS9        713 EESISILTSMGFpRHHTIQALKASNNNLERALDWI 747  zebrafish
XP_001952484  689 EEAAAMIMSMGFeRNHVIAALKATENNLDRALDWI 723  pea aphid
EAL63538      131 EENIQILENMGFpRSRAIEVLTRTNNNINEAASII 165  Dictyostelium discoideum AX4
XP_001009910 1254 NADVKQLEEMGFpRRRAIEALRRCNNNIDEAIDNL 1288 Tetrahymena thermophila
EFA83751      143 EENIAMLVSMGFpRNLAVEALQRTNNNLNDATNFL 177  Polysphondylium pallidum PN500
EGG15445     1729 DINIATLESMGFpRERVIEALQMSNNNLNEATNYL 1763 Dictyostelium fasciculatum
EEB12288      696 ETSISQIMDMGFtREQAMRALKKTNNNIDAACDWI 730  human body louse
EFC44440       10 EDSISQIVDAGFgRDQAIQALRKCNNNVERAFDLL 44   Naegleria gruberi strain NEG-M
AAF56476      424 PRSIIRLMEMGYeRRLVVEALKRTKNNLDRSLDLL 458  fruit fly

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap