1P3Q,1MN3


Conserved Protein Domain Family
CUE_VPS9_like
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cd14369: CUE_VPS9_like 
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CUE domain found in vacuolar protein sorting-associated protein 9 (VPS9) and similar proteins
VPS9, also called vacuolar protein-targeting protein 9, is a cytosolic yeast protein required for localization of vacuolar proteins, such as the soluble vacuolar hydrolases CPY and PrA. It may bind and act as an effector of a rab GTPase and plays a role in vacuolar protein sorting (VPS) pathway. VPS9 contains a region called GBH domain that is related to mammalian Ras-binding proteins, Rin1 and JC265, and may negatively regulate Ras-mediated signaling in yeast Saccharomyces cerevisiae. This model corresponds to the N-terminal CUE domain that interacts specifically with monoubiquitin and regulates intramolecular monoubiquitylation.
Links
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Statistics
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PSSM-Id: 270552
Aligned: 20 rows
Threshold Bit Score: 49.5295
Created: 24-Jul-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptide
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:1P3Q; Saccharomyces cerevisiae vacuolar protein sorting-associated protein Vps9 in complex with ubiquitin, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #   # ### ###  #   #   ##  ###   ###      
1P3Q_Q        11 ERKDTLNTLQNXFPDXDPSLIEDVCIAAASRIGPCVDALLSL 52  baker's yeast
EGV64496     415 TIKETYNQLKEIFPNLDSAILKDIVIMNKGGMDESLEACLQI 456 Candida tenuis ATCC 10573
XP_002492410 564 ERETTLKNLKQMFPDMDSEILLDIAIAKNSNIGDCIDACLEL 605 Pichia pastoris GS115
XP_001384436 702 RLKEVYNNVKEIFPTIDTSILKDLVYINRGDIDKCIDACLQF 743 Pichia stipitis CBS 6054
EDK37962     682 TMKSIYDNLTEIFPNIDSTVLKDLIVIKKGNQDECVEACLQL 723 Pichia guilliermondii ATCC 6260
XP_002615859 686 QVEKTLNQLTEIFPNLDRAVLRDVIVLKKADFDSSLDACLQL 727 Clavispora lusitaniae ATCC 42720
EGW30519     478 QLSEAYDTLREVFPNLDKNILKDIIYLNRGDVDVCIDACLQL 519 Spathaspora passalidarum NRRL Y-27907
XP_002769994 768 AMKETYKSLREVFPNLDKAVLKDVVFMNQGKLDESLDACLQL 809 Debaryomyces hansenii CBS767
XP_003685078 495 ENRHILKNLTSMFPDMLPEIIEDICLAKKYNLGECVDALLSL 536 Tetrapisispora phaffii CBS 4417
CCK71419     418 DNEEALDTLQSMFPDIDKDIIHDIGEAKRYRIGECVDALLQI 459 Kazachstania naganishii CBS 8797

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