Conserved Protein Domain Family
CUE_DEF1_like
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cd14368: CUE_DEF1_like 
CUE domain found in fungal RNA polymerase II degradation factor 1 (DEF1) and similar proteins
DEF1, also called RRM3-interacting protein 1, is a RNA Polymerase II (RNAPII) degradation factor that may be required to couple arrested RNAPII to the proteasome to facilitate its degradation. It contains a CUE domain that is responsible for the binding of ubiquitin. The family also includes many uncharacterized hypothetical proteins. They show a high level of sequence similarity with DEF1.
Links
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Statistics
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PSSM-Id: 270551
Aligned: 35 rows
Threshold Bit Score: 57.9808
Created: 23-Jul-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A6ZZR2         22 LKSKIDTLTELFPd-WTSDDLIDIVQEY--DDLETIIDKITSG 61   Saccharomyces cerevisiae YJM789
CCA36532       26 ESTKLATLTELFPd-WTAQDLEPVLEEYpdEDLNVIIENIISG 67   Pichia pastoris CBS 7435
A5E406         31 ASPELTSLTEMFPd-WESDELNSLLQEKr-NSLEVVIDLIVNN 71   Lodderomyces elongisporus NRRL YB-4239
EAZ63483       22 NSAELASLAEMFAd-WDADELAGLLAENn-NDVEVVIDLIING 62   Pichia stipitis CBS 6054
XP_002173329   60 PESKVNVLRELFPe-WTEEDLHDALRESd-NDLEITILHISEG 100  Schizosaccharomyces japonicus yFS275
XP_002835696   57 YAAELSRLQEMFPa-WTPDDIVTALNENg-GDVQLTASKISEG 97   Tuber melanosporum Mel28
O43024         78 RDSQLSVLQELFPs-WTIDDLSFALEEAd-RDLELTILHITEG 118  Schizosaccharomyces pombe 972h-
EGP89787       64 YFVELGMLKDMFPt-WTDTDLVFALEEAd-GDLPSCVDKITQG 104  Mycosphaerella graminicola IPO323
EGV60161       23 NSLELNNLSEMFPd-WSKEDLSSLLSENn-NDFEKVIDLIVSG 63   Candida tenuis ATCC 10573
EME88671       57 YANQIAMLKDMFGadWTDTDLALVLNDDn-GDTSAVAEKIISG 98   Pseudocercospora fijiensis CIRAD86
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