Conserved Protein Domain Family
UBA_Ubx1_like

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cd14351: UBA_Ubx1_like 
UBA-like domain found in yeast UBX domain-containing protein 1 (Ubx1) and similar proteins
Ubx1, also called suppressor of high-copy PP1 protein (Shp1), is the substrate-recruiting cofactor of AAA-adenosine triphosphatase Cdc48 in Saccharomyces cerevisiae. In concert with ubiquitin-like Atg8, Cdc48 and Ubx1 are involved in the regulation of autophagosome biogenesis. Ubx1 also functions as a regulator of phosphoprotein phosphatase 1 (PP1) with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression. All family members contain an N-terminal ubiquitin-associated (UBA)-like domain.
Statistics
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PSSM-Id: 270536
Aligned: 26 rows
Threshold Bit Score: 52.8606
Created: 24-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P34223         6 DETIQQFMALTNv-SHNIAVQYLSEFG-DLNEALNSYY 41  Saccharomyces cerevisiae S288c
NP_567380      6 QEAIDTFISITGa-SDAVALQKLEEHRgDLNQAVNAYF 42  thale cress
ABK24403       7 QDAIETFMSITGa-SEAAAVEKLQAYAgDLNEAVNAYF 43  Sitka spruce
AAD17337       6 RDAIQSYMSITGa-SESLAIQRLEEHGnNLPEAINAHF 42  thale cress
XP_650206     11 NESIETFIKTTGa-SAKVAEFYLKQYP-DISDAINAFF 46  Entamoeba histolytica HM-1:IMSS
XP_002142432   4 SDEVEQFLSVTGckDRLIAQQYLDLYPnNINDAVNEYF 41  Cryptosporidium muris RN66
XP_666105      3 SNEVENFINISGctDPQIAKMYLEMYPgDMNSAINEYF 40  Cryptosporidium hominis TU502
ACU18678       4 PDAVAAFMRITGa-PEFVAVRKLEEYGsNLNEAINAHF 40  soybean
XP_004133881   6 QEAIETFMRITGa-SESLALRKLEEYRgNVNAAVNSHF 42  cucumber
Q5ADL9        13 TQLRQQFCELTGt-SNTTATKYLESVRyDLARAIDNYY 49  Candida albicans SC5314
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