1BDX,1IXS,1CUK,2H5X,2ZTC,1BVS


Conserved Protein Domain Family
UBA_RuvA_C
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cd14332: UBA_RuvA_C 
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C-terminal UBA-like domain of holliday junction ATP-dependent DNA helicase RuvA
RuvA, along with RuvB and RuvC proteins, is involved in branch migration of heteroduplex DNA in homologous recombination that is a crucial process for maintaining genomic integrity and generating biological diversity in all living organisms. RuvA has a tetrameric architecture in which each subunit comprised of three distinct domains. This model corresponds to the C-terminal domain of RuvA which is distantly related to the ubiquitin-associated (UBA) domain. It plays a significant role in the ATP-dependent branch migration of the hetero-duplex through direct contact with RuvB. Within the Holliday junction, the C-terminal domain makes no interaction with DNA.
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Statistics
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PSSM-Id: 270517
Aligned: 225 rows
Threshold Bit Score: 31.6531
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BDX_A       158 DAEQEAVAALVALGYkPQEASRMVSKIarp-------dasSETLIREALR 200 Escherichia coli BW2952
YP_003995430 151 EDRQDVVDALTALGYkISEINKALRKIsfed------giaVSEKIRQVLS 194 Halanaerobium sp. 'sapolanicus'
Q3SGT1       145 GASDDVRQALLALGYnERETAATVRELpag--------laVGEAIRQALR 186 Thiobacillus denitrificans ATCC 25259
Q3AKG6       158 ESGADVEATLSMLGYdDLEVRRAIRAIaegsdgppppgddQDAWLRGCLQ 207 Synechococcus sp. CC9605
Q2JNW8       156 PIREEVEMALLALGYsTQEIQAALQALpth-------prpTEDWLRDAIT 198 Synechococcus sp. JA-2-3B'a(2-13)
P73554       159 ALLEDLEMTLLALGYtQTEIQQAIAMVsqvpdv--aqsedPEVWIRQAIG 206 Bacillus subtilis BEST7613
B0JRV0       159 AILEDVQMTLLALGYsQEEIDRAMAVLsqdalf--skntqPEDWIKGAIN 206 Microcystis aeruginosa NIES-843
B1XL12       157 AVHEDLELTLLALGYqETEIRGAIATLsqdsil--lqndnADEWIRRAIT 204 Synechococcus sp. PCC 7002
Q31KU1       156 AVQEDVEMTLLALGYnNREILQALTAIaqenlv--qsgqpAEDWIREAIA 203 Synechococcus elongatus PCC 7942
NP_440914    159 ALLEDLEMTLLALGYtQTEIQQAIAMVsqvpdv--aqsedPEVWIRQAIG 206 Synechocystis sp. PCC 6803
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