Conserved Protein Domain Family
UBA_TNK1
?
cd14328: UBA_TNK1 
UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
TNK1, also called CD38 negative kinase 1, is a non-receptor protein tyrosine kinase (NRPTK) that has been implicated in the regulation of apoptosis, cell growth, nuclear factor-kappaB, and Ras. It associates with phospholipase C (PLC)-gamma1 and may play a role in phospholipid signal transduction. TNK1 contains an NH2-terminal kinase, a Src Homology 3 (SH3) domain, a proline-rich (PR) region, and a C-terminal ubiquitin-association (UBA) domain.
Links
?
Statistics
?
PSSM-Id: 270513
Aligned: 19 rows
Threshold Bit Score: 64.1519
Created: 10-Aug-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q13470        624 AIRNLKVDQLFHLSSrsRADCWRILEHYqWDLSAASRYVL 663  human
AAD55428     1031 ATRHYKIDQLARLGVagRPQCEQALQQTnWSLEVAAELLL 1070 fruit fly
XP_970817     534 TVKHVKIDKLLKLGLasRERCEAALQRTnWNVELAASAIL 573  red flour beetle
XP_001945801  892 SVKYLKINNLLRLGMasREACVTALNNCnWNVEEAASTLC 931  pea aphid
XP_003746077 1823 ALRQIKLDHLVRLGIapRQVCENALRNHqWNVDQAASALL 1862 western predatory mite
XP_320737    1041 AVRHFKIERLCRLGLanRTRCEEALQKTgWSIQLAASILL 1080 Anopheles gambiae str. PEST
CAG05457      967 SAAPLQVEQLFRLGLrsRGECEELLQRCnWNLEESSSLVL 1006 spotted green pufferfish
EFX79806      863 AVRFLQVEKLYRLGLcsKAVCVKALEATsWDLEKAASSLL 902  common water flea
EEB13780      965 AIKFIKLDRLLRLAVasREECEAALTRNnWDLNLAASSVL 1004 human body louse
EMP37638     1079 AEKVQLVEQLFCLGLktRGECHRVLEMFdWNLEQASCHLL 1118 green seaturtle
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap