Conserved Protein Domain Family
UBA_II_E2_pyUCE_like
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cd14314: UBA_II_E2_pyUCE_like 
UBA domain found in a putative ubiquitin conjugating enzyme from plasmodium Yoelii (pyUCE) and similar proteins
P. Yoelii ubiquitin-conjugating enzyme and other uncharacterized family members show high sequence similarity to the human Huntingtin interacting protein-2 (HIP2) which belongs to a class II E2 ubiquitin-conjugating enzyme family. These proteins may play roles in the ubiquitin-mediated protein degradation pathway. They all contain a C-terminal ubiquitin-associated (UBA) domain in addition to an N-terminal catalytic ubiquitin-conjugating enzyme E2 (UBCc) domain.
Links
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Statistics
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PSSM-Id: 270499
Aligned: 12 rows
Threshold Bit Score: 62.3396
Created: 23-Jul-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Based on structural evidence that Homo sapiens ubiquitin-conjugating enzyme E2-25 kDa (2O25) forms a complex with Sumo-1- conjugating enzyme Ubc9.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ####                #  #   #
CAQ40734     163 REVIIKKITEMGFTEDQAKNALINADWNETLALNTLL 199 Plasmodium knowlesi strain H
XP_002112784 164 FHEKVRKLSETGFSDDSCRTALSKSGWDEQRGMETLL 200 Trichoplax adhaerens
ACI64339     164 EDAAIDKVCEMGFDRESARKALEKHKWDEGAAVNDLL 200 Thalassiosira pseudonana CCMP1335
XP_002140906 162 KDQKIRRLLDMGFSKDNVTEALIRNKWDETQALNDLL 198 Cryptosporidium muris RN66
XP_002785618 149 HEEKIKNMCDMGFPREMVVKALESNNWDETVALNSLL 185 Perkinsus marinus ATCC 50983
CBJ30375     318 NEDVVRRVCDMGFPEAQARRALASNDWDETAAINTLL 354 Ectocarpus siliculosus
EGR30577     157 QDEKVKKLVEMGFEEKQCREALMKFGWEEELSLNYLL 193 Ichthyophthirius multifiliis
AET50656     165 QEDKVKKLADMGFDKETARTALMNANWDETSALNSLL 201 Eimeria tenella
CCF74909     169 YLKQINKIVEIGFTREQAEKALSVNNWDETIALNYLL 205 Babesia microti strain RI
BAM39231     170 KEGKIKTLLEIGIERDLAVKALEENGWDTTVALNRLL 206 Theileria orientalis strain Shintoku
EJY66901     157 VDDKVRKLMEMGFPEDMCRDALQRYDMDENLALNYLL 193 Oxytricha trifallax
XP_666164    112 KEERIKRFLDMGFNRESIITALERNNWDENLALNELL 148 Cryptosporidium hominis TU502

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