UBA domain found in plant ubiquitin-conjugating enzyme E2 27 and similar proteins
UBC27, also called ubiquitin carrier protein 27, functions as a class II ubiquitin-conjugating (UBC) enzyme (E2). E2, together with E1 (ubiquitin-activating enzyme UBA) and E3 (ubiquitin ligase), is required in the multi-step reaction of ubiquitin conjugation. Unlike other Arabidopsis UBCs, in addition to an N-terminal ubiquitin-conjugating enzyme E2 catalytic domain (UBCc), UBC27 has an additional C-terminal ubiquitin-associated domain (UBA).
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
Comment:Based on structural evidence that Homo sapiens ubiquitin-conjugating enzyme E2-25 kDa (2O25) forms a complex with Sumo-1- conjugating enzyme Ubc9.
Jiyao W et al.(2023). "The conserved domain database in 2023.",