1TTE


Conserved Protein Domain Family
UBA_II_E2_UBC1
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cd14311: UBA_II_E2_UBC1 
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UBA domain of yeast ubiquitin-conjugating enzyme E2 1 (UBC1) and similar proteins
UBC1, also called ubiquitin-conjugating enzyme E2-24 kDa, or ubiquitin-protein ligase, is the yeast homolog of mammalian ubiquitin-conjugating enzyme E2 K (UBE2K or E2-25K). UBC1 and UBE2K are unique class II E2 conjugating enzymes, both of which contain a C-terminal ubiquitin-associated (UBA) domain in addition to an N-terminal catalytic ubiquitin-conjugating enzyme E2 (UBCc) domain. The yeast UBC1 plays an important role in the degradation of short-lived proteins especially during the G0-G1 transition accompanying spore germination.
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Statistics
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PSSM-Id: 270496
Aligned: 18 rows
Threshold Bit Score: 46.1156
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Based on structural evidence that Homo sapiens ubiquitin-conjugating enzyme E2-25 kDa (2O25) forms a complex with Sumo-1- conjugating enzyme Ubc9.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ####                         #  #     
1TTE_A       167 GIDHDLIDEFESQGFeKDKIVEVLRRLGVksldpndnntANRIIEELLK 215 baker's yeast
Q6C353       164 GLDRDAVEGFASMGFgKDKIIAVFKKLQIkkpq--sqedEQRVVEELLN 210 Yarrowia lipolytica
EGG03698     167 GLNPAYVQQFETMGFqRHQIIEVMKKLNYrgknv-sllgEDAVIEALLS 214 Melampsora larici-populina 98AG31
EFW98085     182 GIDRATVQIFEDMGFpKDKIIAALRKLDLkkirvddvqtQQSVLDEILH 230 Pichia angusta DL-1
XP_002493859 190 GIEIASIEMFENMGFsRPKILDVLKKLGLtrvedndgdtKQEILEELLR 238 Pichia pastoris GS115
EIM21606     164 GLAQNDVNKFTSMGFlENNVIEVLSALDYrgnni-qnisDDIVVEQLLS 211 Wallemia sebi CBS 633.66
EMS22894     186 GLNWEDVSAFSEMGFpAEQVIDVLKRLNYrdgnk-dkvgEDAVIQRLVG 233 Rhodosporidium toruloides NP11
CCA75984      31 GLNVVHIQQFEALGFeRQKVIDVMKRLNYggvng-tkiaDDKWLKSSCR 78  Piriformospora indica DSM 11827
EJD40020     142 KVEQVHIDRFVELGFpQDTVEKVLNELRYvgqnv-gkidDNVVVDECQR 189 Auricularia delicata TFB-10046 SS5
EKJ74652     180 GYNKDLVERFVNMGFpLDNVVEAFIAIGIern-----ggRDYVLEEAYM 223 Fusarium pseudograminearum CS3096

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