2G3Q


Conserved Protein Domain Family
UBA_scEDE1_like

?
cd14285: UBA_scEDE1_like 
Click on image for an interactive view with Cn3D
UBA domain found in Saccharomyces cerevisiae EH domain-containing and endocytosis protein 1 (Ede1) and similar proteins
Ede1, also bud site selection protein 15, is the mammalian protein Eps15 homolog found in yeast and functions at the internalization step of endocytosis. Both Ede1 and Eps15 are endocytic scaffold proteins that may involve in stabilization of the adaptor-cargo complex. They both contain contains three N-terminal Eps15 homology (EH) domains and C-terminal ubiquitin-binding motifs. Whereas Eps15 has two ubiquitin interacting motifs (UIM), Ede1 harbors a single ubiquitin-associated (UBA) domain. This model corresponds to Ede1 UBA domain that is responsible for the binding of monoubiquitinated proteins and negatively regulates EH domain-mediated protein-protein interactions.
Statistics
?
PSSM-Id: 270471
Aligned: 5 rows
Threshold Bit Score: 57.9996
Created: 23-Jul-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
polypeptide
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:2G3Q; Saccharomyces cerevisiae Ede1 UBA domain in complex with ubquitin, contacts at 4A.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         #  ####                 ### ##  # 
2G3Q_A       7 AVEELSGMGFT--EEEAHNALEKCnWDLEAATNFLLD 41   baker's yeast
CCH61814  1378 AIEELSGMGFT--QEEARKALEQCnWDLDAATNFLLD 1412 Tetrapisispora blattae CBS 6284
CCF56358  1225 AIEELSGMGFA--EEEAKNALEKCnWDLEAATNLLLD 1259 Kazachstania africana CBS 2517
NP_983097 1190 AVEELGSMGFT--EQEARKALEKCkWNLEAATNMLLD 1224 Ashbya gossypii ATCC 10895
EJD74695   839 KIEELLSMGVAqdRGQAVSALEDCrWDLNAAAAALIS 875  Loa loa

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap