4HPL


Conserved Protein Domain Family
PUFD
?
cd14261: PUFD 
Click on image for an interactive view with Cn3D
PCGF Ub-like fold discriminator of BCOR
The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Links
?
Statistics
?
PSSM-Id: 271224
Aligned: 6 rows
Threshold Bit Score: 211.242
Created: 7-May-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
RAWUL domain
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:RAWUL domain interface [polypeptide binding site]
Evidence:
  • Structure:4HPL: the PUFD domain of BCOR binds the RAWUL domain of polycomb group ring finger protein 1, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1               ## ##### ### # #        # #                                         ### ##
4HPL_A          1 METRSDVFEFEFSEtPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSC 80   human
AAI63892     1670 EDEQRDVFEFEFSDrPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSC 1749 zebrafish
EMP31504     1613 EDGYSDVFEFEFSDgPLLPCYNIQVCLSQGPRNWLLLSDIVKRLKMSSRIFRCNFPNVEVVTITEAEFYKQTSLSQLFSC 1692 green seaturtle
NP_001120151 1492 DDGYMDAFEFEFSDsPLLPCYNIQVSLSQGPRNWMLLSEVTKRLKMSSQTFTAENPHLEIVTITEAEFYKQVSLSQLFSS 1571 western clawe...
CAF95793      214 QRARREVFEFELSDrPLLPCYNVQVSLSQGPRNWLLLSDVLGRLRMTSRSFRRLFPQLNVQSVPEDEFYRQASLSQLLTG 293  spotted green...
Q6W2J9       1630 DDAYSDVFEFEFSEtPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSC 1709 human

Feature 1          #  #                #          # # ###
4HPL_A         81 SK--DLEAFNPESKELLDLVEFTNEIQTLLGSSVEWLHP 117  human
AAI63892     1750 PE--ELEGFMPDSKELLDLVEISGELVALLGSSIECLDD 1786 zebrafish
EMP31504     1693 AK--DLEAFNPESKELLDLVEFTSELQTLLGSSLEWLHP 1729 green seaturtle
NP_001120151 1572 PE--GLEGFSPDSREMVELVEFTNELQTLLGSSIEWIDP 1608 western clawed frog
CAF95793      294 PDeqELASFRPDIKDPLELVEATPELAGMLGSSLDPEAK 332  spotted green pufferfish
Q6W2J9       1710 SK--DLEAFNPESKELLDLVEFTNEIQTLLGSSVEWLHP 1746 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap