4HPM


Conserved Protein Domain Family
PUFD_like_1
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cd14260: PUFD_like_1 
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PCGF Ub-like fold discriminator of BCOR-like 1
The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Links
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Statistics
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PSSM-Id: 271223
Aligned: 5 rows
Threshold Bit Score: 185.053
Created: 7-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RAWUL domain
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:RAWUL domain interface [polypeptide binding site]
Evidence:
  • Structure:4HPM: The PUFD domain of BCoR-L1 binds the RAWUL domain of polycomb group ring finger protein 1, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ########### # #        ### #                                        ## #  #
4HPM_A       2 ETRDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAE 81   human
AAH73676  1164 DLEDNFLFEFSDKPLLYCYNLHVSLTSGPSNWFLFSDVLKHLKLSSRIFQARHPHFEVARMQKKEFTKQVLTSQLLTPTE 1243 African clawed frog
CAG09845  1278 TDKDCLVFEFSSEPLLPCYHIQVSLTQGFCNWFLLTDVLKRLKMSARIFRARYPHLEVVSLLRTELWEQVLVSQVSTALG 1357 spotted green pu...
EMP32090  1470 QESDSFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATLPKAEFQRQVSSSQLLAQEE 1549 green seaturtle
Q5H9F3    1591 MEEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAE 1670 human

Feature 1                               #          # #
4HPM_A      82 RPgg----ldDRSPPGSSETVELVRYEPDLLRLLGSEVE 116  human
AAH73676  1244 GL--------DLWPQDMGDIVELVKYEPELLRLLGSAVE 1274 African clawed frog
CAG09845  1358 SPhkekkeenDEEEEEEQELIELVRCVPELQRLLGSSIH 1396 spotted green pufferfish
EMP32090  1550 VPes-----pEPRPQGPAETVELVRYEPELLQLLGSAVE 1583 green seaturtle
Q5H9F3    1671 RPgg----ldDRSPPGSSETVELVRYEPDLLRLLGSEVE 1705 human

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