2VN6,1OHZ,4DH2,3UL4


Conserved Protein Domain Family
Dockerin_I
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cd14256: Dockerin_I 
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Type I dockerin repeat domain
Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type I dockerins, which are responsible for anchoring a variety of enzymatic domains to the complex.
Links
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Statistics
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PSSM-Id: 271215
Aligned: 226 rows
Threshold Bit Score: 44.0693
Created: 3-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site [ion binding site], 9 residue positions
Conserved feature residue pattern:D [NDT] x x D [DEN] x x DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two dockerin repeats bind two calcium ions
  • Structure:1OHZ: dockerin repeats from Clostridium thermocellum Endo-1,4-beta-xylanase Y bind calcium ions, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # # # #    #                                # # #      #         
2VN6_B         4 YGDYNNDGNVDSTDFAGLKKYIMAad-------------hAYVKNLDVNLDNeVNAFDLAILKKYLL 57   Clostridium cellulolyticum
1OHZ_B         1 MGDVNGDGTINSTDLTMLKRSVLRait----------ltdDAKARADVDKNGsINSTDVLLLSRYLL 57   Clostridium thermocellum
YP_005846019 365 YGDVNGDGCLDILDILMVVDHIIGrdslegeaflradlapWVPGTPEPNPDGvVNVQDLSLLQNIIL 431  Ignavibacterium album Mat9-16
YP_004105606  30 YGDINGDGKTDVTDISLAAAYIKGkkp----------lteEQLFLGDLNYDEkLNVTDLAKLASYVK 86   Ruminococcus albus 7
YP_004105748  28 KVDINLDGKVNVTDLSMLSAYIKGkka----------iytSVVSSADLNRDGrVNVTDISMLASYVK 84   Ruminococcus albus 7
YP_004105471 475 KYDINSDGNVNITDASVMTAHILSrka----------mnsSSLKKADIDKNGrFEVTDAILVIKYLK 531  Ruminococcus albus 7
YP_004103906 758 LGDVNYDKRFNSADIDMINEYLSGnndf--------silqKNLASIDYDNNKvINEDDIDALENLIQ 816  Ruminococcus albus 7
YP_001741849 675 YGDVTSEGIINMQDIAFINQYAIGldpipei--dlrpweaYRITNADVDGNGtIDAFDSYLLCKYIY 739  Candidatus Cloacamonas acid...
YP_007688323  39 RGNANDDHTINSDDMAIVQDIINGtr------------nkDDFPLADVNDDGkVNETDVSLLQDLID 93   Thermoplasmatales archaeon ...
YP_844005     27 FGNANMDDTIDESDIAYTRGIIDGk--------------eKNTEFADANYDGkVDSRDIEQIQHIIQ 79   Methanosaeta thermophila PT

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