2B59,2Y3N,2JNK


Conserved Protein Domain Family
Dockerin_II
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cd14254: Dockerin_II 
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Type II dockerin repeat domain
Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type II dockerins, which are responsible for mediating attachment of the cellulosome complex to the bacterial cell wall.
Links
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Statistics
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PSSM-Id: 271213
Aligned: 37 rows
Threshold Bit Score: 50.2811
Created: 3-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site [ion binding site], 10 residue positions
Conserved feature residue pattern:D [NDV] [NDST] x [DE] [DENS] [NDT] [DN] x [ED]Click to see conserved feature residue pattern help
Evidence:
  • Structure:2B59: Type II dockerin repeats from Clostridium thermocellum cellulosomal scaffolding protein A bind two calcium ions, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # # # #    #                        # # # #    #         
2B59_B        101 GDIVKDNSINLLDVAEVIRCFNatk---gsaNYVEELDINRNGAINMQDIMIVHKHFG 155  Clostridium thermocellum
NP_981324    1322 GDVNGDKVIDIKDAEIIANNYGkk------gLSVKDGDLNKDGIVDEKDIRFVEKNFL 1373 Bacillus cereus ATCC 10987
YP_007211899  846 GDFNDDNRVSIGDLALVAKAYGmtsd-spnwNEVKRYDINNDGIIDIEDLSAVARLIL 902  Thermobacillus composti KWC4
YP_001877615 1090 GDINNDGKIDRNDLTSYINYTGlrkgdsdfeGYISNGDINKNGLIDAYDISVVATQLE 1147 Akkermansia muciniphila ATCC BAA-835
2JNK_A         82 GDFNGNGKIDIGDLAMVSKNIGs--------TTNTSLDLNKDGSIDEYEISFINHRIL 131  Clostridium perfringens
NP_691157    1276 GDVNQDDVIDIEDAILIKEHWN---------SSHRNTDINFDGTVDSEDINFVVSNYL 1324 Oceanobacillus iheyensis HTE831
NP_562182    1299 ADINEDGSINVGDLSIVSKYQGevi---sgnALSEKSDINKDGVVDKADIQIVMGKIL 1353 Clostridium perfringens str. 13
NP_691652      15 GDINQDSVIDIIDALLMVKYWG---------SDKQAADFNFDGTGDKKDFELLAANFL 63   Oceanobacillus iheyensis HTE831
YP_003009045  131 GDLNNNSVIDVGDLSVLIKYFGiasd-dpnwTKVANGDFNKNNTIDVQDLASLGKKVL 187  Paenibacillus sp. JDR-2
YP_004484167   33 GDVNKDGSINIADVVYLFKHRD---------LNIEDGDLNADNSIDIADVVYLFVNYQ 81   Methanotorris igneus Kol 5

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