Conserved Protein Domain Family
ESP36_like

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cd14250: ESP36_like 
Exocrine gland-secreting peptide 36 (ESP36) and similar pheromones
ESP36 is a peptide pheromone expressed only in the female mouse extraorbital lacrimal gland. This family also includes the juvenile pheromone ESP22 which is secreted from the lacrimal gland and released into the tears of 2-3 week old mice. ESP22 activates the vomeronasal response pathway, and inhibits male sexual behavior. This small family appears restricted to rodents; the functions of other members have not yet been determined.
Statistics
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PSSM-Id: 271209
Aligned: 23 rows
Threshold Bit Score: 41.2622
Created: 1-May-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative receptor binding site [polypeptide binding site]
Evidence:
  • Comment:residues involved in c-Fos induction in the vomeronasal organ

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #   #            # ##                 #   #   #
BAF92751      23 TQKEPKISADHKTNGNivfeeidCKNMRINIEDVGHNLqgsYQINIQFQGLFNDF 77  house mouse
BAF92737      28 TQKESIFSAEHKSDLKsylemlvCRRLRDVPESVIHISk--VSKEILPDDLLSTY 80  house mouse
NP_001171056  28 DQEELIDSEDESIILIs------CQYIQEFLKNAGEILfysNDKEVMFEKIIDRD 76  house mouse
BAF92761       5 IQKESISSADQKKNVKshsemivCQRLTYTKGDVQMFKg--SREDQILYVLESSY 57  Norway rat
BAF92741      22 TQRELTTSTDYTVLVD-------CDYIRVVSNLVAMIFledHKDNKFYENEPSDF 69  house mouse
NP_001231692  28 TEKEPEISADLKDDFKip----lCQTIRNNIDVCWLSIg-sDKDKPLFLGFIINF 77  house mouse
BAF92736      28 TEEEPNISADLKVDFKlp----vCQTKRNDIEFIWMSSg-sDQDGVLFLPFRFHI 77  house mouse
NP_001171057  28 DQEELIDSEDEQLIFIe------CGYIQGILHNPEMSFn-lNDYEQKFENINNRV 75  house mouse
NP_001242980  28 TEEEPHISADLKVDFEip----vCQSKINDINVMLMSRv-sDQGGVLFLPFRFVL 77  house mouse
BAF92740      28 TQEELTTSTDSLVLFD-------CNYIQSISNSVANLIledHKDNTFLKTEPKDI 75  house mouse

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