2LMK


Conserved Protein Domain Family
ESP
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cd14248: ESP 
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Exocrine gland-secreting peptide 1 (ESP1) and similar pheromones
ESP1 is a peptide pheromone found in male mouse tear fluid, which is recognized by a specific G-protein-coupled receptor in the vomeronasal sensory neurons and affects female mouse sexual receptive behaviour. This small family appears restricted to rodents. ESP36 is expressed only in the female mouse extraorbital lacrimal gland. The juvenile pheromone ESP22 is secreted from the lacrimal gland and released into the tears of 2-3 week old mice; it activates the vomeronasal response pathway, and inhibits male sexual behavior. Information regarding other members of this family is not yet available.
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Statistics
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PSSM-Id: 271207
Aligned: 3 rows
Threshold Bit Score: 63.543
Created: 2-Mar-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative receptor binding site [polypeptide binding site]
Evidence:
  • Comment:residues involved in c-Fos induction in the vomeronasal organ
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   #            # ##                 #   #   #
2LMK_A      6 PQEVQRALARILCal------gELDKLVKDQANAGqqeFKLPKDFTGRSKCR 51  house mouse
BAF92751   26 EPKISADHKTNGNivfeeidckNMRINIEDVGHNLqgsYQINIQFQGLFNDF 77  house mouse
BAF92737   31 ESIFSAEHKSDLKsylemlvcrRLRDVPESVIHISk--VSKEILPDDLLSTY 80  house mouse

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