3ECQ,2ZXQ


Conserved Protein Domain Family
GH_101_like
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cd14244: GH_101_like 
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Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases
This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates.
Links
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Statistics
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PSSM-Id: 271203
Aligned: 48 rows
Threshold Bit Score: 267.984
Created: 2-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic siteactive site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:D D EClick to see conserved feature residue pattern help
Evidence:
  • Comment:Three acidic sidechains participate in the hydrolysis of O-glycosidic bonds
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #                     
3ECQ_A       564 PQGWKKVKDITAYRIAXNFgsQAQNPFLXTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLnyadigkriGGVEDFKT 643  Streptococcus ...
EGG86445     282 DFYDAENPDKNNHLTPFSV--RTEEIKKFHELGVGKLYLHLDGWAEPGYDNQHPDYLPACEKA---------GGWKAMKE 350  Lachnospiracea...
ADL03610     281 RFFDPENPDKNNHVYSFEKr-TGEIRRFHKDLGLKKLYLHLDGWAEPGYDNQHPDYLPACEEA---------GGWEKMKE 350  Clostridium sa...
EET58672     282 ELYDPENPEKNNRVVTFRQ--RGEEMRALQRLGVRKLYLHLDGWGEAGYDNRHPDYPPACKEA---------GGWEEMKA 350  Bryantella for...
EDS07292     282 DFFDKDAPDINNQLVSFAK--REEEIRELNAAGVKKLYMHLDGWAEPGYDNQHPDYVPACEAA---------GGWEKMRS 350  Clostridium sc...
EGN39527     293 DFYDKTDPEKNNHVTSFTV--REMQMGNLRKMGVKKLFLHLDGWADPGYDNKHPDYRNACKEA---------GGWEGMKD 361  Lachnospiracea...
EHL10804     285 EFFDKDAPDKNNRLVPFKK--RTEEMKAFKADGVEKLYLHLDGWGDAGYDNKHPDVGPACAEA---------GGWEGMRE 353  Oribacterium s...
NP_696006    280 YYYDKDHPEKNDSLVTFAQ--REKQMRTLHGMGAGRLYMHLDGWAQPGYDNAHPDYLPACQEA---------GGWEGMKS 348  Bifidobacteriu...
ZP_09543070  273 RFYDAKKPDRYESLTTFAT--RRQEMIEWKQLGVNKLYLHLDGWGVEGYDNAHPSILPPCEKA---------GGWDGLQA 341  Eubacterium sp...
ZP_06645915  273 RFYDAKKPDRYESLTTFAT--RRQEMIEWKQLGVNKLYLHLDGWGVEGYDNAHPSILPPCEKA---------GGWDGLQA 341  Erysipelotrich...

Feature 1                                                                                        
3ECQ_A       644 LIEKAKKYGAHLGIHVNASETYPESkyfnekilr--knpdgsysyGWNWLDQGINIDAAYDLahgRLARWEDLKKKLgdG 721  Streptococcus ...
EGG86445     351 LSDTMHECGYLFGIHDQYRDYYYAAktfdenfatrladgtipshaRWAGGPQTYLCATQAPFy--VKRNFTEIMDNGi-K 427  Lachnospiracea...
ADL03610     351 LADTMHEYGYSFGIHDQYRDYYRRArtfdqnfaaqkpdgtltehaNWAGGPQTYLCATQAPYy--VKRNFTEIKKNGi-T 427  Clostridium sa...
EET58672     351 LADTVHACGYLFGVHDQYRDYYQNApsfdenfacrlpdgtiprhrRWAGGSQAYLCATQAPGy--VKRNFSELKEMGi-K 427  Bryantella for...
EDS07292     351 LVDAMHECGYLFGIHDQYRDYYHSApsydddyacmlpdgtipqhqRWAGGPQSYLCGTQAPYy--VKRNFKELKKNRi-E 427  Clostridium sc...
EGN39527     362 LVNTVHRCGFLFGIHDQYRDYYLDAdtfdeeyavrftdgtipkhkRWAGGPQTYLCGTQAPYy--VKRNFQDLFRHGi-K 438  Lachnospiracea...
EHL10804     354 LSKTMEELGYLFGIHDQYRDFYKKAesydddfacksadgsiyshaRWAGGPQAYLCTIQAPYy--VRRNFERLLKEGv-H 430  Oribacterium s...
NP_696006    349 LVDACHEQGDIFGTHDQYRDYYFTAqtfdannairladgtmpehaRWAGGRQTYLCAELAPDy--VRRNFTQIAAHGi-K 425  Bifidobacteriu...
ZP_09543070  342 LCQQMKQLHYVFGLHDQYRDHYHLGkeydpqnsvqlpdgsipshaYWAGGEQDYLCASLASSy--VKRNYEALFAHGi-Y 418  Eubacterium sp...
ZP_06645915  342 LCQQMKQLHYVFGLHDQYRDHYHLGkeydpqnsvqlpdgsipshaYWAGGEQDYLCASLASSy--VKRNYEALFAHGi-Y 418  Erysipelotrich...

Feature 1              #                               #                                         
3ECQ_A       722 LDFIYVDVWGngqsgdNGAWATHVLAKEINKQGWRFAIEWGHGGEYDSTFHHWAADLTYggytNKGINSAITRFIRNHQK 801  Streptococcus ...
EGG86445     428 LDCAYLDVFTcne-gdECSHPWHKMTRRECYEYRNTCFEYLLSKGILPSSEEVNDWAIPs---LVFCHYAPYDFMLDRPG 503  Lachnospiracea...
ADL03610     428 LDCAYLDVFTcne-pdECNHPWHRINRKECLDYRSLCFEYLLSQGILPSSEEVTDWCVKs---LVFCHYAPYSFMMHEPG 503  Clostridium sa...
EET58672     428 LDCAYLDVFTcne-gdECCNPEHRMTRRDCYEFRNWCFDYLLSEGILSSSEEVNDWSVPs---LVFCHYAPYDFMLEAPG 503  Bryantella for...
EDS07292     428 LDCAYLDVFTcne-gdECNNPRHRMTRKECYDARASCFNYLMSQGILPSSEEVSDWCIPs---MVFSHYAPYDFMLREPG 503  Clostridium sc...
EGN39527     439 LDGAYLDVFTcne-gdECDNPRHRMTRRECYEYRKQCFDWLLARGIMTSSEEVSDWSMQs---LIFCHYAPYSFMLKSPG 514  Lachnospiracea...
EHL10804     431 LDGAYLDVFTcne-gdECANPRHTMRRRDSYEYRNACFRYLLSKNILPSSEEVNDWAVPw---LVFCHYAPYDFMLREPG 506  Oribacterium s...
NP_696006    426 LDCAYLDVFTcne-gdECSNPEHRMTRRECFDRRAECFEYLLSHGILSSSEEVSDWAVPs---LIFCHYAPYDFQMRSPN 501  Bifidobacteriu...
ZP_09543070  419 PDAVYLDVFTcne-pdECAHPMHRMTRRECLAYRNACFAWLLSKHILTSSEEVNEWALPy---QIFAHYGPYHFMMHSPK 494  Eubacterium sp...
ZP_06645915  419 PDAVYLDVFTcne-pdECAHSMHRMTRRECLAYRNACFAWLLSKHILTSSEEVNEWALPy---QIFAHYGPYHFMMHSPK 494  Erysipelotrich...

Feature 1                                                                               
3ECQ_A       802 DAWVgdyrsyg-------gaanypLLGGYSXKDFEGWq-gRSDYNGYVTNLFAHDVXTKYFQHFTVSKWEN 864  Streptococcus pneumonia...
EGG86445     504 SPKKgipvplfnlvyhdcliepwmMDKVSEEEDYMLYavlNGGAPYLVRDGAYQNTDGSFAGGVEISIEDQ 574  Lachnospiraceae bacteri...
ADL03610     504 AKRQgigvplfnlv-yhdcmiipwMMEKYEKEDFMLYallNGGAPYFIRDGAYENIDGSFGGHQALSEKEM 573  Clostridium saccharolyt...
EET58672     504 SPKQgipvplynlvyhdcviqpwmMDKVSEEEDYMLYallNGGAPYLIREAAYPGIDGAFLAEKNAADIKE 574  Bryantella formatexigen...
EDS07292     504 SPKYgvpvplfnlvyhdcliepwmMEKVSDSEDYMLYallNGGAPYVIRDGAYPNFDGSFEPDVKLTLDQD 574  Clostridium scindens AT...
EGN39527     515 TSREgipvplfnlvyhdcvlepwmMDKTEGMEDFMGYallNAGMPYLLRDGAYENMDGSFTDSSGMWIEEM 585  Lachnospiraceae bacteri...
EHL10804     507 SPKYgipipmfnlv-yhdcliipwMMEKLPEEDYMLYallNGGAPYLVRDPAYMGIDGAFTLEEEMPWKTH 576  Oribacterium sp. ACB8
NP_696006    502 EPRQgvpvplynlvyhdcviepwmMERVVDGDDYMLYallNGGAPYLIRDAAYIGVDGDMDDEQRARTEND 572  Bifidobacterium longum ...
ZP_09543070  495 EERIgigvplfnlvyhdcvllpwpMDVYLDGEDLMLYallNGGAPYLEKDGAYPNTDGVFDNEYKSLTKQE 565  Eubacterium sp. 3_1_31
ZP_06645915  495 EERIgigvplfnlvyhdcvllpwpMDVYLDGEDLMLYallNGGAPYLEKDGAYPNTDGVFDNEYKSLTKQE 565  Erysipelotrichaceae bac...

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