1WRD


Conserved Protein Domain Family
GAT_TOM1_like

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cd14233: GAT_TOM1_like 
Click on image for an interactive view with Cn3D
canonical GAT domain found in target of myb protein 1 (Tom1) protein family
Tom1 and its related proteins, Tom1L1 and Tom1L2, form a protein family sharing an N-terminal VHS (Vps27p/Hrs/STAM)-domain followed by a GAT (GGA and TOM1) domain, both of which are also conserved in Golgi-localized gamma ear-containing Arf-binding proteins (GGAs). In contrast to GGAs, the Tom1 family proteins bind to ubiquitin, ubiquitinated proteins, and Toll-interacting protein (Tollip) through its GAT domain, but do not associate with Arf GTPases through its GAT domain nor with acidic cluster-dileucine sequences through its VHS domain. In addition, the Tom1 family proteins recruit clathrin onto endosomes through their C-terminal region. In their C-terminal clathrin-binding regions, Tom1 and Tom1L2 are similar to each other, but distinguishable from Tom1L1. The yeast S. cerevisiae does not contain homologous proteins of the Tom1 family. The canonical GAT domain is a monomeric three-helix bundle that binds ubiquitin.
Statistics
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PSSM-Id: 410581
Aligned: 29 rows
Threshold Bit Score: 115.753
Created: 6-Sep-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ubiquitin
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:ubiquitin binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ##  ## ##  ##  #                #  ##                                   
1WRD_A         8 IGKLRSELEMVSGNVRVMSEMLTElvptq----aepaDLELLQELNRTCRAMQQRVLELIPQIa---NEQLTEELLIVND 80  human
Q4S7T7       225 EAKLRHELALVKGNLTVMSEMLNElipgqsqkddaqcCRCVFKQLYSVCKNMQTRVVELIPQLe---DEGFIEELLMVND 301 spotted green p...
GAA49261     174 RVKLTQDLSVVETNVNVLNDMLAElrpds----vsqdDLVLLQELVQTCRAMHRRVIEFLSQVs---DDEVTPSLLQVSD 246 Clonorchis sine...
XP_003369721 218 LAKLRSELDVVNGNLAVFREMLSElnpgn----eapdDWALLQELHSTCNEMQNRIIELIQQIs---NDDVTRELLVLND 290 Trichinella spi...
CCD80249     327 ELDEDEDLSIVETNINVLNDLLAElrpdt----vtvdDLNLLKELNCTCRIMHQRVMEFLSQVs---DEEVTNNLIQVNE 399 Schistosoma man...
AAH56566     223 KLKLRSELDLVRGNLTVMTEMLNHtkpge----ttaaDAELLQQLYSVCVQMQQRVVELIPHVs---EDDLIGELLLLND 295 zebrafish
AAI55259     225 MKTIKAELEVVRNNLSVMSDMMNQmepat----fepsDTELLQQLYSMTKDMQSRMVEVIPTLt---DEKLTEQLLNAND 297 zebrafish
O75674       202 IGKLHSELDMVKMNVRVMSAILMEntpgs----enheDIELLQKLYKTGREMQERIMDLLVVVe---NEDVTVELIQVNE 274 human
CBY08844     448 IQRLKSDLGIVEKNIKVFSDIITEtpvpg---tenanDAALLPKLDKSCHEMQDRLSQLLSNLdpgaHAEVFMDALRVND 524 Oikopleura dioica
XP_019853424 211 IAKLLSELDVVRRNLDVMNEILVEnepgk----esedDYSLMQELNTTMRSMQERVTILIGRVq---DEIVMESLLQIND 283 Amphimedon quee...
Feature 1                      
1WRD_A        81 NLNNVFLRHERFER 94  human
Q4S7T7       302 DLNNAFIRYERFDR 315 spotted green pufferfish
GAA49261     247 NLNSAFLRYDRFER 260 Clonorchis sinensis
XP_003369721 291 ELNTVFDKYERYVQ 304 Trichinella spiralis
CCD80249     400 NLTNTLSRYDRFER 413 Schistosoma mansoni
AAH56566     296 ELNNAFIRYQRFDR 309 zebrafish
AAI55259     298 DINTTFTQYHRFEK 311 zebrafish
O75674       275 DLNNAILGYERFTR 288 human
CBY08844     525 ELNNIFLRYERFCR 538 Oikopleura dioica
XP_019853424 284 ELNGCFTRYDRHMK 297 Amphimedon queenslandica

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