2X7G


Conserved Protein Domain Family
STKc_SRPK2
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cd14217: STKc_SRPK2 
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Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPK2 mediates neuronal cell cycle and cell death through regulation of nuclear cyclin D1. It has also been found to promote leukemia cell proliferation by regulating cyclin A1. SRPK2 also plays a role in regulating pre-mRNA splicing and is required for spliceosomal B complex formation. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 271119
Aligned: 4 rows
Threshold Bit Score: 776.516
Created: 19-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #####   #            # #                                   # 
2X7G_A        20 YHPVKIGDLFNgRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQ 99   human
NP_001165329  64 YHPVKIGDLFNgRYHVIRKLGWGHFSTVWLCWDMQGKGFVAMKVVKSAQHYTETALDEIKLLRCVRESDPRDPNKDMVVQ 143  African clawed...
XP_002666802  69 YHPVKIGDLFNsHYHVIRKLGWGHFSTVWLCWDIQGKRFVAMKVVKSAQHYTETALDEIKLLRCVRETDPEDPNKDMVVQ 148  zebrafish
XP_415955    300 YHPVKIGDLFNgRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPNDPNKDMVVQ 379  chicken

Feature 1                          ####  #                                         # # ## #      
2X7G_A       100 LIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSkCKIIHTDIKPENILMCVDDa 179  human
NP_001165329 144 LIDDFKISGMNGTHVCMVFEVLGHHLLKWIIKSNYQGVPIHCVKSIIRQVLQGLDYLHSkCKIIHTDIKPENILMCVDDa 223  African clawed...
XP_002666802 149 LIDDFKISGVNGIHVCMVFEVLGHHLLKWIIKSNYQGLPLPCVKSIIRQVLQGLDYLHSkCKIIHTDIKPENILMCVDDa 228  zebrafish
XP_415955    380 LIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPIRCVKSIIRQVLQGLDYLHSkCKIIHTDIKPENILMCVDDa 459  chicken

Feature 1                                                                                        
2X7G_A       180 YVRRMAAEATEWQKAGAPPPSGSAVSTAPa-------------------------------------------------- 209  human
NP_001165329 224 YVRRMAAEATEWQKAGAPPPSGSAVSTAPpqkpigkisknkkkklkkkqkrqaellekrlqeieelereaeqkktdetvs 303  African clawed...
XP_002666802 229 FVRRMAVEATEWQKAGAPPPSGSAVSTAPqlkqvgkisknkkkkmkkkqkrqaellerrmleiealereaekqradgeti 308  zebrafish
XP_415955    460 YVRRMAAEATEWQKAGAPPPSGSAVSTAPqqkpvgkisknkkkklkkkqkrqaellekrlqeieelereaerkkieenvt 539  chicken

Feature 1                                                                                        
2X7G_A           --------------------------------------------------------------------------------      human
NP_001165329 304 stvllneqdleghpeakmktvcledatdeepvneherggkdekedtqkenvekgdgdededddddddddaepelvdtdqt 383  African clawed...
XP_002666802 309 aehgptladseedeeeeedeeeeekqrpvrltnhtseeldgsgdgrqeeeekaeevekaeeveeetaaapsesteeetrq 388  zebrafish
XP_415955    540 savpsneqedeyhpevklktadleevvdeepgnddgeaedqdekedtekentekdddveqelvsndptdpkwiespk--- 616  chicken

Feature 1                                                                                        
2X7G_A           --------------------------------------------------------------------------------      human
NP_001165329 384 w------------------------iespktnghlengpfcvesqleddeedddclnpvefnldesnvesdytysssyeq 439  African clawed...
XP_002666802 389 cvkedeqtkhtrdtqdeeeeeeeeddeedeedeeeeeeeeeqstaaktnghvcvcvqecvspaaptllcplveseisttd 468  zebrafish
XP_415955    617 ------------------------------tnghivngpflleqqiededdeeeecpnpeeynldepnaksdysysssye 666  chicken

Feature 1                                                                                        
2X7G_A       210 ----------------------------------------------------------------------------aDLL 213  human
NP_001165329 440 fngelpngphknselqvsefstsvfpealesaacglavseesaltdrdesrscqdrsrtvsasstgdfpktsklqaaDLL 519  African clawed...
XP_002666802 469 rdasdasyelfngdtsslsngarhrgttprfpelpldpdpthtlqdqaqgpdrhsdrsrtvsssstgdnpkariraaDLL 548  zebrafish
XP_415955    667 qfngelpngrhkipesqfsefsasvfsgalesvacgsavsegstvtereesspshdrsrtvsasstgdlpktktraaDLL 746  chicken

Feature 1                         #                                                              
2X7G_A       214 VNPLDPRNaDKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGaGYSTPADIWSTACMAFELATgDYLFEPHSGEDY 293  human
NP_001165329 520 VNPLDPRNaDKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGaGYSTPADIWSTACMAFELATgDYLFEPHSGEDY 599  African clawed...
XP_002666802 549 VNPLDPRNaEALRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGaGYSTPADIWSTACMAFELATgDYLFEPHSGEDY 628  zebrafish
XP_415955    747 VNPLDPRNaDKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGaGYSTPADIWSTACMAFELATgDYLFEPHSGEDY 826  chicken

Feature 1                                                                                        
2X7G_A       294 SRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYgWPHEDAAQFTDFLIPMLEMVPE 373  human
NP_001165329 600 SRDEDHIALITELLGKIPRKCAMLGKYSKDFFTKKGELRHITKLKPWSLYDVLVEKYgWPQEDAAQFTDFLTPMLEMVPE 679  African clawed...
XP_002666802 629 SRDEDHIAHIIELLGCIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYgWAAEEAGHFTHFLLPMLEMVPE 708  zebrafish
XP_415955    827 SRDEDHIAHIIELLGNIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYgWPHEDAAQFTDFLIPMLEMVPE 906  chicken

Feature 1                      
2X7G_A       374 KRASAGECLRHPWL 387  human
NP_001165329 680 KRASAGECLRHPWL 693  African clawed frog
XP_002666802 709 KRASASECLHHPWL 722  zebrafish
XP_415955    907 KRASAGECLRHPWL 920  chicken

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