Conserved Protein Domain Family
PTKc_Aatyk3
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cd14206: PTKc_Aatyk3 
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk3, also called lemur tyrosine kinase 3 (Lmtk3) is a receptor kinase containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. The function of Aatyk3 is still unknown. The Aatyk3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).
Links
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Statistics
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PSSM-Id: 271108
Aligned: 4 rows
Threshold Bit Score: 601.171
Created: 17-Aug-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs.
  • Citation:PMID 9312016
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #####   #              # #                                             #### 
Q96Q04        135 YLQEIGSGWFGKVILGEIFSDytpAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQ 214  human
AAI36191      137 YLQEIGNGWFGKVILGEIFSDytpAQVVVKELRVNASPLEQRKFLSEAQPYRSLQHSNILQCLGLCTETIPFLLIMEFCQ 216  western clawe...
XP_003225907  136 YLQEIGNGWFGKVILGEIFSDftpAQVVVKELRVNAGPLEQRKFISEAQPYRSLQHPNILQCLGLCTETIPYLLIMEFCQ 215  green anole
XP_004078219  255 YLQEIGNGWFGKVILAEVLCDcssSQAVVKELRVSASPLEQRKFLAESEPYRSLKHPNILQCLGQCSESIPFLLVMEFCQ 334  Japanese medaka

Feature 1          ##                                                #   ## #          #          
Q96Q04        215 LGDLKRYLRAQRppEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKE 294  human
AAI36191      217 LGDLKRYLRAQRkaDGMTPDLLTCDLTTLQRMAYEITLGLMHLHKNNYIHSDLALRNCLLTSDLTVRIGDYGISHNNYKE 296  western clawe...
XP_003225907  216 LGDLKRYLRAQRkaDGMTPDLLTRDLSTLQRMAYEITLGVLHLHKNNYIHSDLALRNCLLTSDLTVRVGDYGLSHNNYKE 295  green anole
XP_004078219  335 LGDLKRYLRAQRkaDGMTPDLPTRDLLTLQRMAFEITLGLLHLHENNYIHSDLALRNCLLTSDLTVRIGDYGLSHNHYKE 414  Japanese medaka

Feature 1                #####        #                                        #                  
Q96Q04        295 DYYLTPERLWIPLRWAAPELLGELHGtFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARP 374  human
AAI36191      297 DYYITPDRLWIPLRWVAPELLDEVHGnLVVVDQSKESNVWSLGVTMWELFEFGSQPYRHLSDEEVLTFVIKEQQMKLAKP 376  western clawe...
XP_003225907  296 DYYITPDRLWIPLRWVAPELLDEMHGnVIVVDQTKESNVWSMGVTIWELFEFGSQPYRHLSDEEVLTFVVKEQQMKLAKP 375  green anole
XP_004078219  415 DYYLTPDKLWIPLRWIAPELLEEYRGsLIVTDQTKTSNVWSLGVVIWELFEFGAQPHRHLSDEEVLTFVIRERQITLAQP 494  Japanese medaka

Feature 1                                             
Q96Q04        375 RLKLpyADYWYDILQSCWRPPAQRPSASDLQLQLTY 410  human
AAI36191      377 RLKLphSDYWYEVMQSCGLPTEQRPSVEELHLQLTY 412  western clawed frog
XP_003225907  376 RLKLpySDYWYEVMQSCWLPASHRPTMEELHLQVSY 411  green anole
XP_004078219  495 RLKLshADYWYEIMQSCWLPPSQRPSVAEIFLLLSS 530  Japanese medaka

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