Conserved Protein Domain Family
PT_UbiA_5

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cd13967: PT_UbiA_5 
UbiA family of prenyltransferases (PTases), Unknown subgroup
Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.
Statistics
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PSSM-Id: 260130
Aligned: 33 rows
Threshold Bit Score: 192.825
Created: 28-Feb-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1: putative active site [active site], 5 residue positions
Conserved feature residue pattern:D D D D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on homology modeling using structures of trans prenyltransferases that are helical enzymes containing two D-rich motifs in the active site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              #   #                    
ADE36998     19 KRILDFLTYsSVYLSIAGAVMAYMACQLqglalswqtMAIMFLVTYSVYnIDRKADEDEDsinhSERYSFTKKYEK---- 94  Methanohalophilu...
YP_565086    22 AALWKDFIYgGHIFAFGAICVAIMASIIfaipitwdfMLIIYLIFYSIYvYDYFTGAEEDkgnySSRSEYLQKNDE---- 97  Methanococcoides...
ZP_21547258  20 TRALELFVHsNLFISLATMSVVVTTALLtglpiealpLFIVFAVTMFVYtVNRLTDLAEDeenmPDRAALTRQYGR---- 95  Natrialba chahan...
ADQ68922     23 RQATDALVYsSIYLVFIAMVEVATAMFAlslp-pspaPFVVGLVTFSVYvGDRIADRDSDemttPEQSAFVGRHAS---- 97  Halogeometricum ...
CCQ35432     16 EAAVELLVHsNLFISAAATSVALSTMLLvglapdplaLFIVFAATLFVYsLNRITDIDEDrenvPSRADFTERYGR---- 91  Natronomonas moo...
AEG17904     20 SQLQDEIVYgGYLAALCSPAFVFSVSVLanikvglpiLVIAYLIPLMVYsYDYYRDMDKDmatnSERAAYFNKKAK---- 95  Methanobacterium...
YP_325794    16 RDVAVLFVHsNLLISLAATSVAFSTMWLvgvsadpvpLFIVFAATLFVYsLNRLTDIEEDrqnvPRRAAFIERYGK---- 91  Natronomonas pha...
AGB38636     18 LAGLRFLVHsNLFISLSAASVVITTSVLaglpleplpFFIVFAAAMFVYtVNRFTDLEEDrenvPRRAAFVERYGY---- 93  Natronococcus oc...
ADE36467     21 KNLWKEFIYgGHLFAAGAVGVVYMASVFcnifisldfLAAIYLMFYAIYfYDYTTGAEEDketnSERSVYIDADHNqkki 100 Methanohalophilu...
BAI61744     26 FQVKDEFIYgGYLTSLGCPAFVLSVSLLlglavdwpvLLIAYLVPLVVYsYNYYEELEKDvatnPERSGHLGKKVK---- 101 methanogenic arc...
Feature 1                                                                                       
ADE36998     95 FLFLSSILAy---lFAFLLAy-------PYGFKALLVTai-plVSGLLYSFAWLPsgfryrrlk-eipsvknlVIATAWA 162 Methanohalophilu...
YP_565086    98 KMLIGTIYG-----SIVAIAftylifsdIKNMLIGFSIl----ILGLMYHSHFKSitkkfp-------afknlFVSLVWG 161 Methanococcoides...
ZP_21547258  96 LWLAVGAGLy---lLAIVAAv-------AAGVPGAGYMli-plLIAVAYSSGLKQvflv-----------knvVVGLAWG 153 Natrialba chahan...
ADQ68922     98 ILSVLTAVSy---gLAVAIAi-------TGGPLALAITll-pgAFWVLYASDWLPsvggqfkrlkdilvvnsaIVAGAWA 166 Halogeometricum ...
CCQ35432     92 VLLFAGVVLy---lLAIVGAi-------ALGLPGAPFLal-paVAATLYSLFHVKrill----------vknlIVGVSWG 150 Natronomonas moo...
AEG17904     96 IYPFIMASYavllvSLLILF--------SNYELILFILvt--vLVGMLYTFGLKGitkkvp-------gfkniYTALTWA 158 Methanobacterium...
YP_325794    92 PLFAAGVALy---lGAIAVAv-------WLGLPGAPFLil-paVVAALYSTFKIKqrll----------vknlVVGVAWG 150 Natronomonas pha...
AGB38636     94 LWLALGVGLy---lGAIAVAv-------VLELPGAGYLvl-paVVAVLYTFGVKRvflv-----------knlFVGFAWA 151 Natronococcus oc...
ADE36467    101 KLIVCGAALg---mSIIYIIws-----dLTNMVIGFSIl----VLGLLYHSYFKNltrfip-------afknfFVSAVWA 161 Methanohalophilu...
BAI61744    102 LYPVLFGVYm---sLLILLLl-------LFANYVFTIFvlillSCGILYTIVFKDltkqip-------gfkgvYIAAVWA 164 methanogenic arc...
Feature 1                                            #  #   #                                   
ADE36998    163 STPAFlpslvygqAMGDLVFVTFIYFFSLVFVNTVIFDMRDIEGDSisGIDTIPVLLGAEKTRi--lLICLTLASGYFMI 240 Methanohalophilu...
YP_565086   162 LLIYImfiy-ygyQIDMSAMVISAFVFLRMMGIQIMFDIRDMEGDRikGLLTIPAIFGHGKSMs--fLKMLNIVTLILLA 238 Methanococcoides...
ZP_21547258 154 LLPLGvgyy-yqqLWTVEILFLAGYVTAMITVAAVIFDLKDITGDReeGIATVPNVFGPRWTRi--gAQVANVIIAAAVV 230 Natrialba chahan...
ADQ68922    167 IAVVLlpvafadaALTPTTAVVFIYFFVDTFVNTEIPNVRDRKGDAeiGVSTLPVVFGVRRTRq--iLYALDLCLIGFLV 244 Halogeometricum ...
CCQ35432    151 IIPLGvgvy-ygtGTRAGILVLSVFFTTMLTVAAAVFDVKDIEGDRaeGIRTAPIVFGVRATKv--gSLVVTAAVAVGVV 227 Natronomonas moo...
AEG17904    159 IAGTFfiplyysmNLNLAFMLIFLFIFLKCLPNIIFFDIKDIEGDKkeGLKTVPVLIGKENTLn--lLRGMNIIAFLPLF 236 Methanobacterium...
YP_325794   151 IIPLGvgvy-ygvLWTPEVLFAFVFVTVMLTVAAAIFDIKDIEGDRaeGIRTFPIVFSPAATRw--gAAVITVLVAAGVV 227 Natronomonas pha...
AGB38636    152 LIPLGvgvy-yeqLLTLEVLFLAGYVGAMITIAAAIFDIKDIEGDReqGIDTLPTAVGPRRTRl--aAQAANVLVAAVVI 228 Natronococcus oc...
ADE36467    162 LLVFLllay-ysqPITSAAILLSVFIFLRMLKIQILFDLRDTEGDKkkGLLTIPVCMKGNSEKllnmLNVLNLLTIIVIA 240 Methanohalophilu...
BAI61744    165 LAGAFlfnfhysvTWGVFSVLMFSFIFLRGIINVTFFDIKDVESDSarGLKTLPVLLGREKTLk--fLNVLNIFSFIPLI 242 methanogenic arc...
Feature 1                                                                 
ADE36998    241 NTGMqql-gtaSLLVLAAgVIYALCYVIFFGRitgnns-lcdlmaDGQFIILGGLLIV 296 Methanohalophilus mahii DSM 5219
YP_565086   239 FGVYmki-lpiFVLMIMLvMAYSIKYKDKVLMsrndhr--cyilaAGEPVVWAVLVCV 293 Methanococcoides burtonii DSM 6242
ZP_21547258 231 ALVLsgv-lssRFLVVLAmNAYVGVYIPFADPdygply--ygfivDGEHVFLAAVVCV 285 Natrialba chahannaoensis JCM 10990
ADQ68922    245 TAFLagllsiaLTVGILVgLGYALILAAFIGRterygr-lsiageAKHLVVVAIVLCL 301 Halogeometricum borinquense DSM 11551
CCQ35432    228 SLVAagv-larRFLVLLGfLVYVAAYTPFATRdrgplf--ygfviDGEHVFLAALVVV 282 Natronomonas moolapensis 8.8.11
AEG17904    237 AGVYlhlipafTLVMLVF-LAYSFHYMKKASNanademslisqtlADAEFILWPLVLF 293 Methanobacterium sp. SWAN-1
YP_325794   228 VAVAtgv-vshRALVFLSlSAYVFAYIPFASRdrgplf--ygfvvDGEHVFLGAVVLL 282 Natronomonas pharaonis DSM 2160
AGB38636    229 AVIAvdv-ldtRFLVLLAfHGYVGCYIPFASRdrgplf--yggivDGEHVFLAALVLV 283 Natronococcus occultus SP4
ADE36467    241 YGILtdi-ipaASMMILLvFFYGHSYIKDIKAeknvts--hyllaAGEPILWAGLMQS 295 Methanohalophilus mahii DSM 5219
BAI61744    243 LGVYfni-ipaFGLSLLVfYFYDLYYLRKARVvndknlrmisytlADAEFIIWPVVLL 299 methanogenic archaeon SANAE

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