Conserved Protein Domain Family
PT_UbiA_4

?
cd13966: PT_UbiA_4 
UbiA family of prenyltransferases (PTases), Unknown subgroup
Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.
Statistics
?
PSSM-Id: 260129
Aligned: 35 rows
Threshold Bit Score: 192.476
Created: 26-Feb-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative active
Feature 1: putative active site [active site], 6 residue positions
Conserved feature residue pattern:N D D D D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on homology modeling using structures of trans prenyltransferases that are helical enzymes containing two D-rich motifs in the active site

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                 ##  #   #              
ZP_11361206    7 IFKISRFRFWiyTGGTYVVGYALGFsvfgdflr---peyylylFYFFFPANIFIYGVNDYWDEDTDklNPKKDEKEHRVS 83  Methanobacteriu...
NP_280451      5 LFVLSRPRFWlyLAGPVLVGVSYGAttvgelfs---apavvlfSYFLLPANIYLYGINDVFDRDVDetNPKKDGRESRYR 81  Halobacterium s...
ZP_21566636   20 LLTLSRPRFWlyLAGPVLVGVAYAAdsvgdvfa---paaivlfAYFLLPANVFLYGINDIYDREIDavNPKKEEQEVRYR 96  Haloterrigena s...
YP_007283946   7 LLTRSRPLFWlyLAGPALVGAVYAAdspstlts---pvvigivGYFLLPANLFLYGVNDVFDADVDaeNPKKEGIEARYE 83  Halovivax ruber...
ZP_21694627   23 LLRLSRPRFWlyLGGPVIVGVSYAAdgpgelfs---plaialfLYFTIPGNVFLYGVNDIFDADIDehNPKKDDGREVSY 99  Haloarcula japo...
ACZ42951      11 LLKVSRPKFWlyLLGTYALGCILGAdslpalms---wrtlwffVWFTLPANLLLYGVNDLSDYDTDvhNPKKGDWEALVR 87  Thermobaculum t...
EHQ02550      18 VFFLSRPRFWmyVLGTFLVGVISSGnlflyndtt-tllliafgLFFSLPANVFIYGVNDIYDYQTDiyNDKKIKYESVLK 96  Gillisia limnae...
ZP_21643086   23 LFEMSRPIWWihMLLPITFAILYAVdsasqils---vtslwflAYFSLPGNLYVYGMNDAFDVDTDqvNPRKIDDETPSV 99  Haloferax larse...
EJD07247       8 LIRASRVPGW--FFGPILYTIGVIHsrvlpkttldilrsgfqlFCLSFPLCIIVFGVNDVYDYPSDirNPRKHEQSLEGG 85  Fomitiporia med...
ELU40518      89 LLKSSRPPGW--TFGPILYGIGVIYsgiipnsigalaisafqiVTLSFPLCIIVFGINDIHDYKSDllNPRKSVTSLEGT 166 Rhizoctonia sol...
Feature 1                                                                                        
ZP_11361206   84 Vle--rKRLLNVIFLVt-----sFSLILMVF-----------QDNVERIIFTGf-lFLSYFYSAKPLRFKdKPFLDFASN 144 Methanobacteriu...
NP_280451     82 G-----GAAVAVIVAV-------CGVFLGFVaa--------pLPAEAWPYLAAw-fVLATEYSAPPLRFKtTPVLDSLSN 140 Halobacterium s...
ZP_21566636   97 G-----QRIVPAAVALca----vLPLAVLPL-----------VPSDAWPWIGAf-lVLGAAYSAPPVRFKtTPLLDSISN 155 Haloterrigena s...
YP_007283946  84 G-----ERLTIIAVVAsa----vVGLALIPV-----------LSPPATYYLIGf-lLLGAAYSVPPVRFKtRPLLDSVSN 142 Halovivax ruber...
ZP_21694627  100 Rg----DSAVTAIVVAs------GALALLFAl---------vLPTLGIVALLAw-mALSVEYSAPPLRFKtTPFLDSISN 159 Haloarcula japo...
ACZ42951      88 Pe---mRPRLLVAVLIa------VALALPPLl---------gASPLSWLAWLLf-vVLSVIYSAPPIRLKsRPVIDSLSN 148 Thermobaculum t...
EHQ02550      97 Le---kHRSLWITMAIl-----lIPFLPLFFm----------VNVPTKLALMLf-fFTGLFYSATPVRAKsKPPLDVLFS 157 Gillisia limnae...
ZP_21643086  100 Iy---eHDTINTAVILic---glLMASVVFVt----------TDPVVLGLLAIl-gVAAIVYNVPPIRLKaVPFVDAFIT 162 Haloferax larse...
EJD07247      86 IldpiyHDFVLSSARV-------ASALILLSsfipsqssprnFQQPTLTTFIL---FLSWQYSSPPLRLKeRPILDSLSN 155 Fomitiporia med...
ELU40518     167 IlppahHDFVRKAAIAssvgiimVSMIPSFYitsgt-kvepsLQLNSPILSTAglvALGWVYSAPPLRLKeIPIIDSISN 245 Rhizoctonia sol...
Feature 1                                                                   #   #                
ZP_11361206  145 YLYILPGIfayyl------asntIPPIIYMVGAFl------------HISAMHIFSAIPDIKYDRkaGINTTPVFIGVNP 206 Methanobacteriu...
NP_280451    141 GLYVLPAAaayag------vsgtHPPLLAVAGGWl------------WAMGMHTFSAIPDIEPDRaaGIQTTATALGADR 202 Halobacterium s...
ZP_21566636  156 GLYIAPGVaayaa------vagsQPPVLAVLGGWl------------WAMGMHTFSAIPDIEPDRetGIRTTATVLGERR 217 Haloterrigena s...
YP_007283946 143 GLYVLPAGvtyat------iagtHPPALAVLGGWf------------WAMGMHTFSAIPDIDPDRraEIRTTATVLGQPA 204 Halovivax ruber...
ZP_21694627  160 GLYILPGVigyaa------iegvAPPATAVVGAWl------------WAMGMHTFSAIPDIEPDReaGIQTTATFLGESN 221 Haloarcula japo...
ACZ42951     149 VLYVTPMFlgwsl-----yssspPSWRLALAGAC-------------WCAAMHAYSAIPDIVPDTraGVRTVATLLGELG 210 Thermobaculum t...
EHQ02550     158 AIIYVSPAlvgff-----itgntNIQWLAVLGGLi------------WAFGMQTYSAIPDIEADKkaGVNTLAIMLGEKR 220 Gillisia limnae...
ZP_21643086  163 STLLIPPIavyta------isgsLPPLAIIAGAWv------------WGMGYHIIGAIEDIEPDRkaGLLTTATFLGREK 224 Haloferax larse...
EJD07247     156 GALVWLCWal-----------gyTSSGSALFGASagegaekgwllafCTAGVHALGAAADVEADIaaGQRTIATVFGERL 224 Fomitiporia med...
ELU40518     246 GIIVWLSCfigfssarvltgnlnWGLADIPAKGYil---------glVTASVHALGAAADVEADIaaGQRTIATQIGRRG 316 Rhizoctonia sol...
Feature 1                                                                                        
ZP_11361206  207 ALw--lCLIFWMGLSFIVIYLtdffpiSFLVFFYp-LFPLLLLIKRDWSid----dLYWYLPYVNtmlGGLLFISLVIYK 279 Methanobacteriu...
NP_280451    203 ALa--yCAGIWLLSAAVFALVdv--rfGLLLLAYp-VLVFGIRRLQVAVg-----rAYWWYPAVNtlvGMVFTLGGLWGV 272 Halobacterium s...
ZP_21566636  218 TYa--yCGACWLASAAAFGALdl--rlGALMLVYp-GLVAAIATSSVTVd-----rAYWWFPAINtvvGAALTMGGLWRV 287 Haloterrigena s...
YP_007283946 205 ALg--yCVVCWALAAVTFGILdl--riGALLLVYp-LIVGAIATANVTIs-----rAYWWFPAVNstvGMVLTLGGLWRV 274 Halovivax ruber...
ZP_21694627  222 TYy--yCVMCWLMAAFVFNFThw--vfGVLLLVYp-GLVFGILGVGVDId-----eAYWWYPAINtvvGMVFTLIALWVM 291 Haloarcula japo...
ACZ42951     211 TLr--yCLVMYLLAAILVLPSdl--fsGVILMVYp-GIMLAQMRLAPHAva----rWYPYFPLINgvaGMVLTLRFLLPL 281 Thermobaculum t...
EHQ02550     221 ALw--fCLITYLISASIGFYYvg---fIAIVFGIv-YISIVLLSINNISkl---fkYYTYFPLINvltGAVLFFDMFFRE 291 Gillisia limnae...
ZP_21643086  225 TLa--fFLGLWVLAPVLIALEsi--pgAALMSVF--TVSLIYTLVSDKElk----dLYLAIPFIN---VGVFGVVIIGGV 291 Haloferax larse...
EJD07247     225 AAg--fSAALYLLASTTVEPTsfvgiySFVGTVIslVPVFRPEWAHQTFktivyvsVIGATGWIG---ERALGILKSRKA 299 Fomitiporia med...
ELU40518     317 CAligtALMAMISATALVTEAte--gsISIFGVYl-VGGLGLMLSACVNpsp--iwVHRAFQATVy-wTVVSSVVCVGRS 390 Rhizoctonia sol...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap