3KE8,4EB3,4H4C,3DNF


Conserved Protein Domain Family
lytB_ispH
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cd13944: lytB_ispH 
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4-hydroxy-3-methylbut-2-enyl diphosphate reductase
The 4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) reductase (called lytB or ispH) is the terminal enzyme of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, one of the two metabolic routes for isoprenoid biosynthesis. The MEP pathway is essential in many eubacteria, plants, and the malaria parasite. LytB converts HMBPP into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Links
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Statistics
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PSSM-Id: 260116
Aligned: 324 rows
Threshold Bit Score: 236.538
Created: 21-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Structure:3KE8; Escherichia coli IspH with bound Fe-S cluster
  • Structure:3DNF: Aquifex aeolicus LytB binds Fe-S cluster
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                                      
3KE8_B        13 ILLANPRGFCAGVDRAISIVENalaiy-gapiyVRHEVVHNRYVVDSLRERGAIFIEQise-vpDGAILIFSAHGVSQAV 90  Escherichia col...
ZP_04055110   10 VEIDPESGFCFGVIKAVSRAEEilrqehgeplyCLGDIVHNRAQVDRLESLGMRTIDHeqfshlSNARVLYRAHGEPPAS 89  Porphyromonas u...
YP_002308801   4 IEIDCDSGFCFGVMSAIQRAEKelitn--delyCLGDIVHNSQEVVRLQKKGLKIINHeelgriYNKKVLFRAHGEPPST 81  Candidatus Azob...
CBK63919       3 VEIDDKSGFCFGVVRAITEAERalaeg--gtvySLGDIVHNRIEVQRLEQLGLRTVTHadmphlAGCRLFIRAHGEPPTT 80  Alistipes shahi...
ZP_08846293   14 VEIDDQSGFCFGVVRAISKAEEklekn--etifSLGDIVHNDMEVERLQKKGMKTINHhdleqlEDGTVFFRAHGEPPES 91  Anaerophaga the...
ACM91004       4 VEIDSRSGFCGGVIRAISQAERflqes--dhlySLGAIVHNEAELDRLGAEGLRTVASipd-vpEGETVLIRAHGEPPST 80  uncultured bact...
EKD32596       5 VEIDNHSGFCYGVVRAIEQAEKyldkn--kelnSLGSIVHNSTEIERLKGKGLKTIDYsqlselKDKVLFIRAHGEPPSS 82  uncultured bact...
ABB88951       6 VQIDVHSGFCFGVVYAIEMAEDilned--gvlyCLGDIVHNDEEVNRLKKKGLKIIDHeilkelRNEKVLIRAHGEPPST 83  Algoriphagus sp...
YP_676721      3 VIIDKNSGYCFGVEFAIQMAEDematg--eplfCLGDIVHNSMEVERLAKKGLKIIDReelkklSDCKVLIRAHGEPPET 80  Cytophaga hutch...
YP_001995032   3 VNVDMNSGFCFGVQFAIDRVEDemkas--gplySLGDIVHNAVEVERLEKLGLKTITIeefktlKNTRVFIRAHGEPPST 80  Chloroherpeton ...

Feature 1                       #                                                                
3KE8_B        91 RNEAKSRdLTVFDATCPLVTKVHMEVARASrr------geESILIGHAGHPEVEGTMGQYsnpeGGMYLVESPDDVWKlt 164 Escherichia col...
ZP_04055110   90 YTYAAENgIEVVDATCPVVLRLQQKVRQAYlqha--nddtQIVIFGKPGHAEVNGLVGQTd---GKAIVVREPKDLDLvd 164 Porphyromonas u...
YP_002308801  82 YEVANQNsIHIIDATCPVVLQLQKKIQKIYqsfa--ntksQIVLFGRSKHAEVSALVGQTn---GNAIVIESKNDIQQid 156 Candidatus Azob...
CBK63919      81 YAAAREMnIGIIDATCPVVARLQRRVKEAHermr--ptggQVVILGKRGHAEVVGLTGQVa---DPTIVIEREEDLELid 155 Alistipes shahi...
ZP_08846293   92 YKTVKEKnLKLIDATCPVVLRLQKKVQAAWeemq--ekrgQVAIFGKIGHAEVKGLSGQTn---HEAIILEKEEDVRLid 166 Anaerophaga the...
ACM91004      81 YADARRRgLVVIDCTCPVVLKLQEHIREAYarlhadglhgTLLIFGKIGHAEVLGLLGQVd---GDAIVVENRAMLEDal 157 uncultured bact...
EKD32596      83 YKIAKENnLQIIDCTCPVVLKLQERVKKYYkelk--kingQLLIFGKHAHAEVNGLIGQVd---GDAIIIEEISDLDIvd 157 uncultured bact...
ABB88951      84 YQLAIENnLELIDASCPVVLKLQHRIKNSYdk------gdSIYIYGKHAHAEVIGLLGQTr---NEAVVFQDISELDLaa 154 Algoriphagus sp...
YP_676721     81 YQLALENnIELVDASCPVVLKLQNRVKASFdaid--skdgQIVIYGQEGHAEVIGIAGQTg---DKAIVITTEKDLDKid 155 Cytophaga hutch...
YP_001995032  81 YKLALENnIELIDATCPVVMKLQQRIKEFYdr------gyQVLIYGREGHPEVIGLCGQCn---NEAIVLKHADLSDRge 151 Chloroherpeton ...

Feature 1                                                                       #                
3KE8_B       165 vk---neeKLSFMTQTTLSVDDTSDVIDALRKr-------------fPKIVGpr-----kDDICYATTNRQEAVRALAEQ 223 Escherichia col...
ZP_04055110  165 f-----arSIELFSQTTMQEDQLEEMLSLIQSrl-----------sdTATLVs------hNTICQQVSRRIPNIREFAKS 222 Porphyromonas u...
YP_002308801 157 f-----akNIYLFSQTTMFVDDFKEIVKEIENk-------------iIHPIIfs----sfNTICHQMVNRINHIRKFAVQ 214 Candidatus Azob...
CBK63919     156 f-----srPVYFLSQTTQSIGLFERLGAEMRRraa----------daGQVYId-------DTICRQVSNREQHLTEFSGR 213 Alistipes shahi...
ZP_08846293  167 p-----arPVILFSQTTKNPVIFNNIADALKRha------------mPGVEVri-----hDTICRQVSNRTPHLRDFASK 224 Anaerophaga the...
ACM91004     158 pai-dfsqPVEIFSQTTKSPAEYAEICDRVRSl-------------gDRVTVh-------DTICAQVANRHEHLAAFARA 216 uncultured bact...
EKD32596     158 f-----skPVYIFSQTTKNPEEYLEVCEAIKKr-------------iEKVEGpadkfrafNTICGQVSSRHSYLKEFSKK 219 uncultured bact...
ABB88951     155 i-----pkNITLYSQTTKSTDKFYEINALLKE---------------NGITVnt-----nDTICRQVSNRDKELRDFSTK 209 Algoriphagus sp...
YP_676721    156 f-----ekPVTLYSQTTKSTQGFYKMKDLIEArvaea-----gknvdENFEYn-------DSICRQVSNREPQLRKFSKE 218 Cytophaga hutch...
YP_001995032 152 tekidfsrKTVLFSQTTKDTTGFYELKANLENvfrehhaaqnfdsaaTESIVpdf--qakDTICRQVSNRDQKLAAFSKE 229 Chloroherpeton ...

Feature 1                                                                                  
3KE8_B       224 AeVVLVVGSKNSSNSNRLAELAQRmgkrAFLIDDAKDIQEEWVke-----vkCVGVTAGASAPDILVQNVVARL 292 Escherichia coli K-12
ZP_04055110  223 HdRIFFVSDQKSSNGRVLYQNCLEvnpnTTFITYPSELTYDLVpsh----eeSIGVCGATSTSREQLQEIAEII 292 Porphyromonas uenonis...
YP_002308801 215 HnLLLFVAGDNSSNGTILFNECRRanlnTYLISDEKDIQSEWFng-----ikSVGICGATSTPKWLMEKIALSL 283 Candidatus Azobactero...
CBK63919     214 FdAVVFVCGRKSSNGKVLSEVCRRanprTHVVEEASEIDPAWFeg-----aaTVGICGATSTPKWLMQDVADAI 282 Alistipes shahii WAL ...
ZP_08846293  225 HdVVIFVGGVKSSNAQALYEACFSvnpqTHFISSPDDLQPLWFtar----pkSTGVCGATSTPLWLMEKVAEKI 294 Anaerophaga thermohal...
ACM91004     217 HdLILFVAGESSSNGRVLFDLCHRlnprSYRIGAPADIDPAWVrd-----gdHVGVCGATSTPQWLLEMVAEAV 285 uncultured bacterium ...
EKD32596     220 HsVIIFVSGKESSNGKILFELCRSvnpwSFSIECKTEIKREWFse-----gdSVGVCGATSTPKWLLEEVAEYL 288 uncultured bacterium
ABB88951     210 FdKIIFVSGTKSSNGKVLFNVCKEtnpnTYFVSNSDQIESSWFme-----neSVGICGATSTPMWLMEEVKERI 278 Algoriphagus sp. KK10...
YP_676721    219 FdVVIFVSGKKSSNGKALYGVCKQenerSYFVENETEIEPSWIra-----tdNVGICGATSTPMWLMEKVQNYI 287 Cytophaga hutchinsoni...
YP_001995032 230 NeCVIFVAGRKSSNGKVLFEVCKDansnTHFIENQSELERAWFlrpddslveSVGVCGATSTPMWVMQQVAEHI 303 Chloroherpeton thalas...

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