2YOP


Conserved Protein Domain Family
PANDER_like
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cd13936: PANDER_like 
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Domains similar to the Pancreatic-derived factor
FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.
Links
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Statistics
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PSSM-Id: 260110
Aligned: 16 rows
Threshold Bit Score: 122.445
Created: 20-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YOP_A         29 YAYRLLSGGgr------dKYAKICFed----eVLIGEktgnvARGINIAVVNYe--tGKVIATKYFDMye-gdNSGPMAK 95   house mouse
Q9UHN6        234 GARKASWTLlar----tlNSSGLPFg-----sYTFEKd---fSRGLNVRVIDQd--tAKILESERFDTheyrnESRRLQE 299  human
XP_002594510 1061 LEVTILSAGwae----mqQQGYVSFiei--ngARYDRy----YRGFMVIAVDAr--sGDVTRQMTFDTykhaeADLDMAN 1128 Florida lancelet
NP_500183     290 IPVHFFSGEhk------dDHPKMCIgg----rMLFDKdlnsaGRGLNLAMLEPk--tGKVTAVAHFDTye--dESHGLEE 355  nematode
NP_500183      81 MLFRVRSETd-------sQPPFACLnd----iKLFDTdn--iGRGINAAILNGt--tGDIIEKATFDVta--sDEKLMTW 143  nematode
EFA82197      454 VEIKAVSRGigenvpyetTYAKFFLng---eeVKYTA-----SRGLNVMIINQd--nGLIESITTYDThgdanASSQFIT 523  Polysphondyli...
CBJ32989     1474 CELEAASGGkd-----dgNFSRLLV-------RGEDRsc--kEPGMNVLVLTEtldaGGQVATTFATHes-vhASNRLAD 1538 Ectocarpus si...
EKC25544      100 KEIKMGSEL---------QNCGLETacegttiQVFTGdt--dSVMPHVCVGEKie-yIIFSNIKLMEMsl--rDSIDMEE 165  Pacific oyster
XP_002157295  794 RYINIQSSD---------TNAVIKVn-----gQDWSKd----EAGFNLVVLDFf--tGEVDSTESFDTevdggASRAMTN 853  green hydra
XP_002120176 1611 YHVNIESAGfe-----dgNYCKIEVn-----gIDYAAn----QRGHNVVVINPr---TKDITSVYFDTygyasAVKDMIT 1673 Ciona intesti...

2YOP_A         96 FIQSTps-kSLLFMVTHDDGss-kLKAQAKDAIEALg----SKEIKNMKf---rSSWVFVAAKGFELps---------eI 157  house mouse
Q9UHN6        300 FLRFQdp-gRIVAIAVGDSAak-sLLQGTIQMIQERl---gSELIQGLGy---rQAWALVGVIDGGSts---------cN 362  human
XP_002594510 1129 FIRNDipetSIVLVAVRDESs--sKAKECLTALKEIg---aQEPVKTDYr----GNFALVGYKGNVWp----------tW 1189 Florida lancelet
NP_500183     356 WLDAVpt-gYIVAVVSFDEAsn-qLSDMARRIFYEMg----SSMIDRLKf---rASWYFVGQKGIGAy-----------T 415  nematode
NP_500183     144 LLKVPh--aSLLVAASFGDVae-hVSRQSRQLFAAFg----AQKIDNWRv---gNAYAIIGQRGIRR------------G 201  nematode
EFA82197      524 LMNSLan-gRIVAIATMDDWtv-rLSTEAINTLKTKc----GGQILGVYplqyrASCSFIGIVGKSI------------Y 585  Polysphondyli...
CBJ32989     1539 YLNNVpq-gRTVLIAVQEDSsg-nLGNSAKRALLSMga--gTTEIAALGmh-krSSFAMIGRRGAIPg----------sV 1603 Ectocarpus si...
EKC25544      166 FLKGLhe-gDIVIAVINDDAsk-qLKQGAIKEMNSLg----SSAIQNLGf---rDIWYFIGQKGIKGy-----------S 225  Pacific oyster
XP_002157295  854 FINSLap-gKLLLVATRGNAge-lMGNNAYTALGYTgg--rSLLTNHLNn---gDRYVLLGATGNLRsliqedlvqygsD 926  green hydra
XP_002120176 1674 FLDSVpf-eSVIAIAVMDATqgvlFDESDVAFMESLgagggNCPVQTVGv---rDAWAMLTQKVRDTnsl-------pqW 1742 Ciona intesti...

2YOP_A        158 EREKINHSdqsrn-ryagwPAEIQIEGCI 185  house mouse
Q9UHN6        363 ESVRNYENhss------ggKALAQREFYT 385  human
XP_002594510 1190 IQQVNLPSaq--------gPAQIYTKIPL 1210 Florida lancelet
NP_500183     416 PFEDLNIPqgn------nwANPIHTSFCL 438  nematode
NP_500183     202 EAHETVAKflee----ntqQKLFEGCFDL 226  nematode
EFA82197      586 PSQLVSSGntl-----vplPVINTFRLPI 609  Polysphondylium pallidum PN500
CBJ32989     1604 PQVLRMPKkgcatvrqrlpAPKVPMCVDV 1632 Ectocarpus siliculosus
EKC25544      226 EFEEISFAsyd-----gewPKQIKKSLCL 249  Pacific oyster
XP_002157295  927 IAEIKSPIvi-------gpGAMNDTCLCL 948  green hydra
XP_002120176 1743 FQCVYVPKnn--------gIAKIVQYAET 1763 Ciona intestinalis
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