Conserved Protein Domain Family
harmonin_N_like_u1

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cd13933: harmonin_N_like_u1 
domain similar to the N-terminal protein-binding module of harmonin; uncharacterized subgroup
This domain is a putative protein-binding module based on its sequence similarity to the N-terminal domain of harmonin. Harmonin (not belonging to this group) is a postsynaptic density-95/discs-large/ZO-1 (PDZ) domain-containing scaffold protein, which organizes the Usher protein network of the inner ear and the retina. This domain is also related to domains found in several other scaffold proteins which organize supramolecular complexes.
Statistics
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PSSM-Id: 259827
Aligned: 4 rows
Threshold Bit Score: 128.339
Created: 15-Feb-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative protein binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of the N-terminal domain of harmonin to an internal peptide of cadherin, and on the human CCM2 HHD dimerization interface

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #  #   #             #  #  ##  #                                               
EGD78251     8 RSQHVAEFQEMAQHYL-NDHEKVQLQHALTEFKHSK--SVPRLVATLNIVLDTPQKRDLLRPLRFLIPddFALRSAFDKM 84   Salpingoeca sp. ...
EEN59694     5 CPQRFSDLPTPQRTIPdGMSVRWVRDWDVRQTLGGMhqAVDRLVSQLCHVLDTPQKLDLLKEIRKLIP--PQHLPHFDRL 82   Florida lancelet
ELT97721    14 RNQHLSSFITNSRLLL-NEADREYVCTLIKDYQQLR--QVDELMLCLTTLLDTPAKLDLLKDVRHFIS--AENLAKYDRL 88   Capitella sp. I ...
EDQ87741   126 RRFHMQQFTIKATELL-SKPERQVLMDLLAELKRSQ--SVPRFVNGLVHVLETPAKLDLLRWLREVIPtrNDLRKEFDEL 202  Monosiga brevico...
Feature 1         
EGD78251    85 APY 87   Salpingoeca sp. ATCC50818
EEN59694    83 APY 85   Florida lancelet
ELT97721    89 APY 91   Capitella sp. I Grassle & Grassle, 1976
EDQ87741   203 APY 205  Monosiga brevicollis MX1

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