Conserved Protein Domain Family
CuRO_1_2dMco_1
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cd13860: CuRO_1_2dMco_1 
The first cupredoxin domain of bacteria two domain multicopper oxidase
This subfamily includes bacterial two domain multicopper oxidases (2dMCOs) with similarity to McoN from Nitrosomonas europaea. 2dMCO is a trimeric type C blue copper oxidase. Each subunit houses a type 1 copper site in domain 1 and a type 2/type 3 trinuclear copper cluster at the subunit-subunit interface. The 2dMCO is proposed to be a key intermediate in the evolution of three domain MCOs. Multicopper oxidases couple oxidation of substrates with reduction of dioxygen to water. These MCOs are capable of oxidizing a vast range of substrates, varying from aromatic to inorganic compounds such as metals.
Links
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Statistics
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PSSM-Id: 259929
Aligned: 33 rows
Threshold Bit Score: 177.388
Created: 31-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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trinuclear Cuputative trimer
Feature 1: trinuclear Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Trinuclear copper site ligands are typically one or two HxH motifs that can be in the same domain/subunit or in different domains/subunits.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                # #                     
EAY65683     118 KEFHLTAEPVvreMAPGMNANLWGYNGqsPGPTIEAVEGDKVRIFVTNRLpEHTTIHWHGLRlPNGMDGVGGLTQPhipP 197 Burkholderia ce...
EDQ48178      50 KVFHLEANVFkwnILPNKSVDAYGFNGqvPGPRIRIKEGDHIKINVTNHLpEPTTVHWHGLIlDNEMDGAGEITQRpiqP 129 Physcomitrella ...
EKE06316      75 KVFSLIAEPVrwkILNDVTVTAWAYNGmvPGPLIRVTNGDKVRILIKNNLpEPTTIHWHGIQvPNNMDGIPEETQKpieP 154 uncultured bact...
YP_005519159  81 KQFTLTASKFgwnFYRNVNLWAWGYNGqvPGPLIRVRVGDRVEIVVHNDLpEPTTIHWHGMAvPNDMDGVPGFPEPaiqP 160 Alicyclobacillu...
YP_005519160  96 KRFTLVASEVnwyLYPGKSVVACGYNGqvPGPVIRVRVGDRVQILLKNELnEPTTLNFPGLPlPASQLGIGGVTERpvpP 175 Alicyclobacillu...
ADT89770      49 KVFNLEVTEThwmFNDEVMMDAWTYNGtlPGQEIRVQEGDEVVINVKNSLnVPTALHLHGFPvPNEMDGVPGVTQNaimP 128 Bacillus subtilis
EIT84304      43 NRFTLVAQEKmwqLSKNKQVRAWTYGGtvPGTAISVKQGEVVSVKLVNQLkQPISIHWHGVPlPNTEDGIPGQTQDavaP 122 Bacillus macaue...
ACV83921      49 GVKGLEVTEDhwkLQCNVMVEVWTYNGrnDGPEIEVRRGDRVIILNKNDLnHPKTLHVHGEPvPNDMDGLPGNTQEaidP 128 uncultured bact...
YP_003323959 253 KVFNLTAEHVkweVLPGEYIDAYAYNGmvPGPLIRVKEGDRVRIHFKNELpEPTTIHFHGNTlPNSMDGVPDVTQPvvkP 332 Thermobaculum t...
YP_003588206  57 KTWTIVAKPArweIAPGVDVQALTYGGtvPGTTIEVRQGDHVRVKLVNQLsVPTSIHWHGYPvPASMDGVPGITQDpvqP 136 Bacillus tuscia...

Feature 1                            # #                  
EAY65683     198 GKTFVYEFQLe--AHGTFMYHPHADEMvqMAMGMMGMFIVH 236 Burkholderia cenocepacia PC184
EDQ48178     130 GETFTYTFDAv--QSGMYFYHSHYATDrqQSLGLYGMLMID 168 Physcomitrella patens subsp. patens
EKE06316     155 GETFTYEFVAk--PAGTYWYHSHFDSDkqISVGLSGAFIID 193 uncultured bacterium
YP_005519159 161 GGTFVYRFTVtsqMIGTHWYHSHYDDDyqVDAGLNGVIIVD 201 Alicyclobacillus acidocaldarius subsp. acidocaldarius ...
YP_005519160 176 GGERLYSFTVtpdMVGTHLYESGTDMAseIDQGLHGVLLVD 216 Alicyclobacillus acidocaldarius subsp. acidocaldarius ...
ADT89770     129 GEEFTYEYQAn--VPGTYWYHSHQDGAtqVDRGLYGVFIVE 167 Bacillus subtilis
EIT84304     123 NETYTYQFIAk--DAGTYWYHSHQDSVnqVDKGLYGTFVVT 161 Bacillus macauensis ZFHKF-1
ACV83921     129 GNNETYEEANn--LPGTYWYHSHQDPNtwIDRGLYGHDIVE 167 uncultured bacterium
YP_003323959 333 GQSFTYEFKAe--PVGTFIYHTHHNSAiqEPKGLYGVLIIE 371 Thermobaculum terrenum ATCC BAA-798
YP_003588206 137 GQSFVYDFIAt--VPGTYWYHSHMDSAnqVDEGLYGPLIVL 175 Bacillus tusciae DSM 2912

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