3G5W,4E9V


Conserved Protein Domain Family
CuRO_D1_2dMcoN_like
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cd13859: CuRO_D1_2dMcoN_like 
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The first cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins
This family includes bacterial two domain multicopper oxidases (2dMCOs) represented by the McoN from Nitrosomonas europaea. McoN is a trimeric type C blue copper oxidase. Each subunit houses a type 1 copper site in domain 1 and a type 2/type 3 trinuclear copper cluster at the subunit-subunit interface. The 2dMCO is proposed to be a key intermediate in the evolution of three domain MCOs. Its biological function has not been characterized. Multicopper oxidases couple oxidation of substrates with reduction of dioxygen to water. These MCOs are capable of oxidizing a vast range of substrates, varying from aromatic to inorganic compounds such as metals.
Links
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Statistics
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PSSM-Id: 259928
Aligned: 7 rows
Threshold Bit Score: 205.79
Created: 31-Jan-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: trinuclear Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:3GSW; Trinuclear binding site of two-domain multicopper oxidase from Nitrosomonas europaea.
  • Comment:Trinuclear copper site ligands are typically one or two HxH motifs that can be in the same domain/subunit or in different domains/subunits.
  • Comment:There are three trinuclear copper binding sites in between subunits in the functional trimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                # #                     
3G5W_A         3 REFDLSIEDtriVLVGKRDFHTFAFNGQVPAPLIHVMEGDDVTVNVTNMTtLPHTIHWHGMLQrgTWQSDGVPHATQHAI 82  Nitrosomonas eu...
4E9V_A         4 REFDMTIEEvtiKVAPGLDYKVFGFNGQVPGPLIHVQEGDDVIVNVTNNTsLPHTIHWHGVHQkgTWRSDGVPGVTQQPI 83  uncultured bact...
YP_001939585  37 RNFELTIEDtiiTLVKDQKFHTFAFNGQVPGPLIHVKYGDDVTVKVTNLTtLPHTIHWHGILQtgTWQMDGVPNTTQPEI 116 Methylokorus in...
YP_001759801  28 LEFEMTIDEmvaEVTPGFSNKVWAFNGQVPGPLIRAKEGDRLKITVHNNStLAHTVHWHGTLQtnSWKMDGVPGVTQKAI 107 Shewanella wood...
YP_003526637  33 PQQILAKDWe--FDFPIGEMGTFSSEEQIQGPLIHVDEGDDLVVHVKNNTpFKHTIRWHGVYQmdSWHNDGMSEMKKRLL 110 Nitrosococcus h...
EFI52042      34 RHFSMTIEDtvlTLVDKQTFHTFSFNGQTPGPLIHVKEGDDLVIDVENQTtLPHTIHWHGMFQrgSWKNDGVPDTTQPAI 113 Afipia sp. 1NLS2
EAU54314      18 REMNMTIDEvtlPVAPDLNYKVFAFNRQVPGPLIHAKEGDDLVIHVTNNTsLAHTIHWHGFHQmnSWRMDGVPGITQEPI 97  Mariprofundus f...

Feature 1                                  # #                   
3G5W_A        83 e------pGDTFTYKFKAePAGTMWYHCHVNVNEHVTMRGMWGPLIVE 124 Nitrosomonas europaea
4E9V_A        84 e------aGDSYTYKFKAdRIGTLWYHCHVNVNEHVGVRGMWGPLIVD 125 uncultured bacterium
YP_001939585 117 k------pGDTFTYHFKAvPAGTYWYHCHVNVNEHVSMRGMWGPLIVD 158 Methylokorus infernorum V4
YP_001759801 108 e------pGESFVYDFIVdRPGSLWYHCHVNVPEHVGLRGMWGPMIID 149 Shewanella woodyi ATCC 51908
YP_003526637 111 siqkaveaGESFTYRWKAeKTGTFWYHYHINVNEHDGVQGVAVGSKGA 158 Nitrosococcus halophilus Nc4
EFI52042     114 a------pGETFTYRFKAePSGTMWYHCHVNVNEHVAMRGMWGPLIVD 155 Afipia sp. 1NLS2
EAU54314      98 k------pGTTFTYKIKAdRPGTLWYHCHVNVNEHVGIRGMWGPIIID 139 Mariprofundus ferrooxydans

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