3SBT,4I43


Conserved Protein Domain Family
Aar2_N
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cd13777: Aar2_N 
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N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
This family consists of the N-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.
Links
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Statistics
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PSSM-Id: 260099
Aligned: 121 rows
Threshold Bit Score: 62.3086
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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inter-domainheterodimer
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:inter-domain interface [polypeptide binding site]
Evidence:
  • Structure:3SBT: Saccharomyces cerevisiae Aar2 protein N-terminal domain interactions with C-terminal domain; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              #                             # # #                    
3SBT_B      2 NTVPFTSAPi---------eVTIGIDq-ySFNVKEnq--pFHGIKDIPIg--hVHVIHFQhadn---------------- 51  Saccharomyces cere...
CCH46630    8 TTVIFNNIPe---------nWLVGIDl-qFFNTNNi----LKGIKLIPDg---IHILHFAkdq----------------- 53  Wickerhamomyces ci...
CAY71968    1 MFNVLLDLPk---------tFSVGIDg--NFLSSEnspfqLKGIKLVEPg---VHFIHLEdln----------------- 49  Pichia pastoris GS115
Q4YR80    106 NFGKINNSSkehgsfkesikLNVGLDy-sNFSIDTq----YKIIKFITKg---SHFLYWSddvlvgtrnditkefkmnem 177 Plasmodium berghei
EEQ41187    7 TTLVLSSRKaln------snAVIGIDt-qFLTVSDf----LKGIKLIPAg---IHLFHYSdsvdd--------------- 57  Clavispora lusitan...
Q4N6Y9    237 TVVVILDQKe---------dELVGFDf-iSFPEANv----VSGIWNLTPg---SHFMYIKnkeqgnlld----------- 288 Theileria parva
EKX74204   16 TIVIILDQRe---------nELLGFDf-vSLPEANi----VSGIWNLRPg---AHFIYIKddese--------------- 63  Babesia equi
GAB68721  154 DEVNRNTYPrrd-----dtkLHVGLDy-sTFYLDTp----YKIIKCMNKg---SHFLFWGsdtlcgqsdqvtkefkmnem 220 Plasmodium cynomol...
EDO06760   16 TACLVLNQRv---------dEILGFDf-vTFPSSNe----VVGVVNLTPg---CHFVYVKegnsn--------------- 63  Babesia bovis T2Bo
EJY77641    1 MQFGIDNQY-----------WQTGPNfkgIKLIPPgahyvYYALQDEEFaarmGFFIFINeaqeird------------- 56  Oxytricha trifallax

Feature 1             ######      #  #                         # #                            
3SBT_B     52 -----ssmRYGYWFDc---rMGNFYIQYDPkd-------------gLYKMMEErdg-----------akFENIVHnfke- 98  Saccharomyces cere...
CCH46630   54 -----ssiRQGFYINak--eGDIILVYWDSq--------------eEKILVDEei-------------gEININKelski 99  Wickerhamomyces ci...
CAY71968   50 -----lnlRSGIWINg----KDDHTLVIDIkdgisdlsvfivnhmtREMIVKPstdpvdvdysievgkiLDTMSEnf--- 117 Pichia pastoris GS115
Q4YR80    178 kknnceemRNSRFVYfd-aeNKLLVLKYNLkd------------knFQYLKEEnsiyk-------yffdLHKIDFmddnl 237 Plasmodium berghei
EEQ41187   58 ----gtsvRFGRWFEck--rNDIISVEFKDda------------cvFRYLTMV----------------PENLGDly--- 100 Clavispora lusitan...
Q4N6Y9    289 dnivsddcRLGEFIHlk--rGEIKVYKRSQvde----------gslFELVEEYcnq-----------kyKESIVMghl-- 343 Theileria parva
EKX74204   64 ---eadetRFGEFIYlkkgeIKVIRRSADEtg------------spFEIVEDYc---------------NESYKEsving 113 Babesia equi
GAB68721  221 kknnceelRNSRFIFfd-rqKKLLVLKYNIrs------------nsFNYVSESdpi----------yvyFYQLHEknfld 277 Plasmodium cynomol...
EDO06760   64 ---defdrRLGEFVYiy--kDTCTVLKRSKfdh----------gplFEILSEE----------------ESRNYHngiva 112 Babesia bovis T2Bo
EJY77641   57 --sqqeesIDSEIYYt---kQDVIVRKWNSer------------qeFEKVQDQ----------------QEEISYqegvr 103 Oxytricha trifallax

Feature 1                            # ######  # #####
3SBT_B     99 -------rqmMVSYPKide-ddTWYNLTEFV-QMDKIRKI 129 Saccharomyces cerevisiae S288c
CCH46630  100 s----eyysfMINYPNd----eHWEALTKYI-NIGQVAFI 130 Wickerhamomyces ciferrii
CAY71968  118 --------plMVNYSSlntkhpHWESLTKYIsFPRILDVL 149 Pichia pastoris GS115
Q4YR80    238 i---kynkdsIMIYPYty--tkIWKSVTSYI-NDEVINKI 271 Plasmodium berghei
EEQ41187  101 --------qqMVEYPEdh---kAWKSLVSFV-DTEVVEEF 128 Clavispora lusitaniae ATCC 42720
Q4N6Y9    344 -------rgkMSKIPEnl--snLWASMTDCI-NSELILRL 373 Theileria parva
EKX74204  114 -----kfknrMANVPKel--adLWSSMTDCI-NGELINKL 145 Babesia equi
GAB68721  278 dniikekknsILIYPYty--vkVWESLTCYI-NEEVINKI 314 Plasmodium cynomolgi strain B
EDO06760  113 g----hfhgkLSRIPEgl--qqLWFNMTEYI-TEGVINKL 145 Babesia bovis T2Bo
EJY77641  104 n---mdfdkyLGVYPMqn--fqQWQGLSSFI-SKEVIDRI 137 Oxytricha trifallax

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