Conserved Protein Domain Family
TGF_beta_AMH

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cd13757: TGF_beta_AMH 
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins
AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.
Statistics
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PSSM-Id: 381635
Aligned: 14 rows
Threshold Bit Score: 145.588
Created: 16-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # #      #      # ###                  ##  ## ##  #    ##  # ##  #        
P03971       461 PCALRELSVDLraERSVLIPeTYQANNCQGVCGWPqsdrn-prygNHVVLLLKMQVRGaalARPPCCVPTAYAgKLLISL 539 human
CAA61536     545 HCRLQELTIDLrdRNFIVMPtVYAANNCEGPCRLPlstrv-pgyhSHTVLLLGMQERGsplQRAPCCVPVRYSdQLIISV 623 chicken
AAT77729     456 QCHLQSLSVSL--RKFFLEPsRANINNCEGTCGFPlnn-----anNHAVLLNSHIQSGqpvNRSLCCVPVEYDdLCVIEL 528 zebrafish
XP_010870000 484 LCQRHSLTISL--EKFLLTPrETNIFDCRGVCKFPltk-----gnNHAILLNGQDLAP---QHSLCCVPVDYEgLWVVEL 553 northern pike
CCP19124     123 YCRLRELNVDLshETFIQVPkEYLANNCAGPCKLPmsdqn-knynSHVILLMKMQERGmnlKRNPCCIPVKYSgLFVSRF 201 Menado coelacanth
AKE47491     520 DCGLRELSVSLleYKHILQPkDLSIGNCQGHCRFPladsdryehnNHAVLLLRQHERGpglERAPCCVPVMYReVQVTEI 599 Siberian sturgeon
AFA46809     193 ICRVQEHYMQL--ETYVLSPcRASIKKCTGVCSFPlhn-----ptNHAVVIFDQIQSGallDSSVCCVPVAYDsLRVVEL 265 Atlantic cod
AQY62689     439 SCGLRNLSVSL--SMHFASPtTANIKNCQGHCTPPssl-----tnNHAHLLYVHIENGgvgERALCCVPVAYDeLQVVEI 511 Siamese fightin...
ETE62684     576 YCRLRELRINLvsTRYIILPeSYNANNCVGPCQSPlstri-pdyySHTIFLLRMHEQGmplQRAPCCVPVKYSkSLMVTF 654 king cobra
AWT24621     586 YCRLHQLYISLkyEGFILAPdRYLANNCQGPCTDLgaarn-prytTHVILLIKMKNRGeelGRRPCCVPVQYTsSKMAHF 664 West African lu...
Feature 1                   ### #     #
P03971       540 see-riSAHHVPNMVATECGCR 560 human
CAA61536     624 sae-glEVRKFPNMVAEECGCR 644 chicken
AAT77729     529 ese-ttNISYKTNVVATKCECR 549 zebrafish
XP_010870000 554 kqs-atEIILKPNMVATKCECR 574 northern pike
CCP19124     202 ien-glELSLYPNMVAEDCGCR 222 Menado coelacanth
AKE47491     600 tvy-gfKVSDKPNMIAVKCGCR 620 Siberian sturgeon
AFA46809     266 mddgttLSHVKENMFAKECGCR 287 Atlantic cod
AQY62689     512 sd--gaYMHIKKDMVAKECGCR 531 Siamese fighting fish
ETE62684     655 tsdqgmIVKAYPDMVAESCGCR 676 king cobra
AWT24621     665 teg-diQIREIPNATVTECGCR 685 West African lungfish

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